SCHEMBL114750

SCHEMBL114750

Nc1nc(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1Br

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.62
MTOR P42345 2/20 0.62
ALDH1A1 P00352 2/20 0.62
TP53 P04637 2/20 0.62
THRB P10828 1/20 0.62
MDM2 Q00987 1/20 0.62
NCOA1 Q15788 1/20 0.62
NCOA3 Q9Y6Q9 1/20 0.62
GMNN O75496 1/20 0.62
NFKB1 P19838 1/20 0.62
DNMT1 P26358 1/20 0.62
THPO P40225 1/20 0.62
HTT P42858 1/20 0.62
RAB9A P51151 1/20 0.62
BLM P54132 1/20 0.62
HBB P68871 1/20 0.62
PMP22 Q01453 1/20 0.62
PYGM P11217 1/20 0.57
MAPT P10636 2/20 0.52
CDA P32320 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2584289 1.00 LMNA (0.62) LMNAMTORALDH1A1TP53THRB
SCHEMBL114751 1.00 LMNA (0.62) LMNAMTORALDH1A1TP53THRB
SCHEMBL28067693 0.93 LMNA (0.55) LMNAMTORALDH1A1TP53THRB
SCHEMBL11207773 0.90 LMNA (0.50) LMNAMTORALDH1A1TP53THRB
SCHEMBL2580878 0.90 LMNA (0.50) LMNAMTORALDH1A1TP53THRB
SCHEMBL11207095 0.89 LMNA (0.49) LMNAMTORALDH1A1TP53THRB
SCHEMBL6722527 0.89 PDE2A (0.50) LMNAMTORALDH1A1TP53THRB
SCHEMBL369266 0.89 PDE2A (0.50) LMNAMTORALDH1A1TP53THRB
SCHEMBL13908141 0.89 PDE2A (0.50) LMNAMTORALDH1A1TP53THRB
Hydrochloric Acid SCHEMBL10885537 0.89 LMNA (0.49) LMNAMTORALDH1A1TP53THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1792 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES, INC. (US) 2025-08-21 US claimed
EP-4601695-A2 MRNA THERAPEUTIC COMPOSITIONS Nutcracker Therapeutics, Inc. (US) 2025-08-20 EP claimed
US-12357664-B2 Optimized oncolytic viruses and uses thereof SATOR THERAPEUTICS (US) 2025-07-15 US claimed
US-12343420-B2 Stabilized polyribonucleotide coding for an elastic fibrous protein EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) 2025-07-01 US claimed
CN-120025389-A Phosphoramidate nucleoside drug compound, and synthetic method and drug application thereof 河南师范大学 2025-05-23 CN claimed
US-20250121046-A1 MRNA THERAPEUTIC COMPOSITIONS NUTCRACKER THERAPEUTICS, INC. 2025-04-17 US claimed
US-20250082742-A1 MRNA THERAPEUTIC COMPOSITIONS MEDICI THERAPEUTICS, INC. 2025-03-13 US claimed
WO-2025024123-A1 NOVEL CITICOLINE DERIVATIVES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-30 WO claimed
CN-118978559-A Synthesis method and medicinal application of phosphoramidate nucleoside prodrug 河南师范大学 2024-11-19 CN claimed
EP-4379052-A2 MRNA PURIFICATION BY TANGENTIAL FLOW FILTRATION Ethris GmbH (DE) 2024-06-05 EP claimed
EP-0983290-A1 METHOD FOR PRODUCING POLYMERS HAVING NUCLEO-BASES AS SIDE-GROUPS Morphochem AG (DE) 2000-03-08 EP claimed
US-6020483-A Nucleoside modifications by palladium catalyzed methods NEXSTAR PHARMACEUTICALS, INC. (US) 2000-02-01 US claimed
EP-0948256-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1999-10-13 EP claimed
EP-0914324-A2 SPECIFIC INHIBITORS OF DNA METHYLTRANSFERASE ENZYME McGILL UNIVERSITY (CA) 1999-05-12 EP claimed
WO-1998051697-A2 METHOD FOR PRODUCING POLYMERS HAVING NUCLEO-BASES AS SIDE-GROUPS MORPHOCHEM AG (DE) 1998-11-19 WO claimed
WO-1998018324-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1998-05-07 WO claimed
EP-0828750-A1 PALLADIUM CATALYZED NUCLEOSIDE MODIFICATION METHODS USING NUCLEOPHILES AND CARBON MONOXIDE NeXstar Pharmaceuticals, Inc. (US) 1998-03-18 EP claimed
WO-1997044346-A2 SPECIFIC INHIBITORS OF DNA METHYLTRANSFERASE ENZYME MCGILL UNIVERSITY (CA) 1997-11-27 WO claimed
WO-1996038460-A1 PALLADIUM CATALYZED NUCLEOSIDE MODIFICATION METHODS USING NUCLEOPHILES AND CARBON MONOXIDE NEXSTAR PHARMACEUTICALS, INC. (US) 1996-12-05 WO claimed
EP-0653439-A2 Stabilized oligonucleotids and the use thereof HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-17 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250121046-A1 MRNA THERAPEUTIC COMPOSITIONS RNMT, RNGTT, NSUN3 LMNA 3363/4885MTOR 4385/4885ALDH1A1 3114/4885
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA RNASE1, POLRMT, TERT LMNA 233/4885MTOR 4147/4885ALDH1A1 2668/4885
US-20250082742-A1 MRNA THERAPEUTIC COMPOSITIONS RNMT, RNGTT, NSUN3 LMNA 3363/4885MTOR 4385/4885ALDH1A1 3114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.