Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CHKA | P35790 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9004469 | 0.87 | GFER (0.36) | TSHRALDH1A1TDP1THRBXDH | |
| SCHEMBL6285109 | 0.85 | GFER (0.41) | TSHRALDH1A1TDP1THRBXDH | |
| SCHEMBL410871 | 0.81 | TAAR1 (0.50) | PYCR1HTR2ATAAR1 | |
| SCHEMBL8854472 | 0.80 | HRH3 (0.41) | TSHRALDH1A1THRBXDHTP53 | |
| SCHEMBL13130154 | 0.79 | THRA (0.41) | ALDH1A1TDP1THRBTP53CYP3A4 | |
| SCHEMBL9004496 | 0.76 | ALDH1A1 (0.33) | ALDH1A1THRBXDH | |
| SCHEMBL1149698 | 0.76 | TAAR1 (0.50) | TSHRALDH1A1TDP1THRBTP53 | |
| SCHEMBL16682341 | 0.76 | GFER (0.59) | TSHRALDH1A1TDP1CYP3A4CHKA | |
| SCHEMBL9004494 | 0.76 | ALDH1A1 (0.33) | ALDH1A1THRBXDH | |
| SCHEMBL5543474 | 0.76 | THRB (0.34) | TSHRALDH1A1THRBXDHTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170182170-A1 | Nitric Oxide Donors | MEDICAL RESEARCH COUNCIL (GB) | 2017-06-29 | — | — | US | disclosed |
| US-20170182170-A1 | Nitric Oxide Donors | MEDICAL RESEARCH COUNCIL (GB) | 2017-06-29 | — | — | US | disclosed |
| US-9629859-B2 | Nitric oxide donors | MEDICAL RESEARCH COUNCIL (NZ) | 2017-04-25 | — | — | US | disclosed |
| US-9629859-B2 | Nitric oxide donors | MEDICAL RESEARCH COUNCIL (NZ) | 2017-04-25 | — | — | US | disclosed |
| US-20150250804-A1 | Nitric Oxide Donors | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2015-09-10 | — | — | US | disclosed |
| US-20150250804-A1 | Nitric Oxide Donors | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2015-09-10 | — | — | US | disclosed |
| US-9045505-B2 | Nitric oxide donors | UNIVERSITY OF OTAGO (NZ) | 2015-06-02 | — | — | US | disclosed |
| US-9045505-B2 | Nitric oxide donors | UNIVERSITY OF OTAGO (NZ) | 2015-06-02 | — | — | US | disclosed |
| WO-2010110684-A1 | NITRIC OXIDE DONORS | SMITH ROBIN ANDREW JAMES (NZ) | 2010-09-30 | — | — | WO | disclosed |
| US-20100240615-A1 | NITRIC OXIDE DONORS | University of Orago (NZ) | 2010-09-23 | — | — | US | disclosed |
| US-20100240615-A1 | NITRIC OXIDE DONORS | University of Orago (NZ) | 2010-09-23 | — | — | US | disclosed |
| US-20090233873-A1 | NITRIC OXIDE DONORS | UNIVERSITY OF OTAGO (NZ) | 2009-09-17 | — | — | US | disclosed |
| US-20090233873-A1 | NITRIC OXIDE DONORS | UNIVERSITY OF OTAGO (NZ) | 2009-09-17 | — | — | US | disclosed |
| WO-2008039085-A1 | TRIPHENYLPHOSPHONIUM THIONITRITE NITRIC OXIDE DONORS | UNIVERSITY OF OTAGO (NZ) | 2008-04-03 | — | — | WO | disclosed |
| US-4226878-A | ANTIINFLAMMATORY, HYPOTENSIVES, ANTIHISTAMINES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1980-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250804-A1 | Nitric Oxide Donors | SQOR, ARG2, TXNRD2 | TSHR 4202/4885ALDH1A1 1246/4885TRPA1 1488/4885 |
| US-20090233873-A1 | NITRIC OXIDE DONORS | SQOR, ARG2, TXNRD2 | TSHR 4202/4885ALDH1A1 1246/4885TRPA1 1488/4885 |
| US-20100240615-A1 | NITRIC OXIDE DONORS | SQOR, ARG2, TXNRD2 | TSHR 4202/4885ALDH1A1 1246/4885TRPA1 1488/4885 |
| US-20170182170-A1 | Nitric Oxide Donors | SQOR, ARG2, TXNRD2 | TSHR 4202/4885ALDH1A1 1246/4885TRPA1 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.