Sugi Predict

Sugi Predict / Compounds / SCHEMBL1150651

SCHEMBL1150651

SCHEMBL1150651

CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX1 P07099 3/20 0.70
▸ TRPM8 Q7Z2W7 5/20 0.53
▸ TRPA1 O75762 2/20 0.53
▸ SLC1A2 P43004 3/20 0.42
▸ SLC1A1 P43005 2/20 0.42
▸ KCNA5 P22460 1/20 0.41
▸ TRPV1 Q8NER1 3/20 0.41
▸ CYP2C9 P11712 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ GRM8 O00222 1/20 0.39
▸ GRM6 O15303 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ APEX1 P27695 1/20 0.39
▸ GRM5 P41594 1/20 0.39
▸ PMP22 Q01453 1/20 0.39
▸ GRM1 Q13255 1/20 0.39
▸ GRM2 Q14416 1/20 0.39
▸ GRM3 Q14832 1/20 0.39
▸ GRM4 Q14833 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3958539 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
SCHEMBL10001722 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
SCHEMBL3958542 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
SCHEMBL464850 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
SCHEMBL6128484 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
SCHEMBL10034575 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
SCHEMBL12381602 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
SCHEMBL2637678 1.00 EPHX1 (0.70) EPHX1TRPM8TRPA1SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL21331609 0.98 EPHX1 (0.68) EPHX1TRPM8TRPA1SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL291654 0.98 EPHX1 (0.68) EPHX1TRPM8TRPA1SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110869365-B Cooling composition 弗门尼舍有限公司 2024-03-29 — — CN claimed
CN-114917190-A Product for masking bitter taste 郑州味千生物技术有限公司 2022-08-19 — — CN claimed
EP-2276356-B1 WARMING SENSATE COMPOSITION FIRMENICH & CIE (CH) 2013-06-19 — — EP claimed
US-8258320-B2 N alkylcarbonyl amino lactone compounds and their use WEI EDWARD TAK (US) 2012-09-04 — — US claimed
US-20120184608-A1 N alkylcarbonyl amino lactone compounds and their use WEI EDWARD TAK (US) 2012-07-19 — — US claimed
EP-2437719-A1 TREATMENT OF EYE DISCOMFORT BY TOPICAL ADMINISTRATION OF A COOLING AGENT TO THE EXTERNAL SURFACE OF THE EYELID Wei, Edward Tak (US) 2012-04-11 — — EP claimed
WO-2010139954-A1 TREATMENT OF EYE DISCOMFORT BY TOPICAL ADMINISTRATION OF A COOLING AGENT TO THE EXTERNAL SURFACE OF THE EYELID WEI EDWARD TAK (US) 2010-12-09 — — WO claimed
US-20080227857-A1 N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use WEI EDWARD TAK 2008-09-18 — — US claimed
CN-119930456-A Method for preparing N-ethyl-L-menthyl formamide by continuous flow technology 安徽科芯微流化工科技有限公司 2025-05-06 — — CN disclosed
CN-115806481-B Separation and purification method of L-menthyl formic acid 安徽丰乐香料有限责任公司 2024-11-22 — — CN disclosed
US-20240360075-A1 N-SUBSTITUTED C6 CYCLYL CARBOXAMIDE COMPOUNDS AND USES THEREOF ALCON INC. (CH) 2024-10-31 — — US disclosed
CN-107949555-B Physiological cooling compound 西姆莱斯有限公司 2024-09-24 — — CN disclosed
US-20240225915-A1 COMPOSITIONS FOR FIGHTING MALODORS SYMRISE AG (DE) 2024-07-11 — — US disclosed
US-20240225915-A1 COMPOSITIONS FOR FIGHTING MALODORS SYMRISE AG (DE) 2024-07-11 — — US disclosed
WO-2008056118-A1 N-ARYL-HYDROXYALKYLIDENE-CARBOXAMIDE COMPOUNDS AND THEIR USE PAGET, HUGH, CHARLES, EDWARD (GB) 2008-05-15 — — WO disclosed
EP-1871738-A2 N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE Wei, Edward T. (US) 2008-01-02 — — EP disclosed
WO-2007138031-A2 MENTHANE CARBOXYLIC ACID N-(ALKYLTHIOALKYL)AMIDES AND USE THEREOF AS PHYSIOLOGICALLY ACTIVE COOLING ACTIVE INGREDIENTS SYMRISE GMBH & CO. KG (DE) 2007-12-06 — — WO disclosed
US-20070155755-A1 N-arylshydroxyalkylidene-carboxamide compositions and methods WEI EDWARD T 2007-07-05 — — US disclosed
WO-2006103401-A2 N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE PAGET, HUGH, CHARLES, EDWARD (GB) 2006-10-05 — — WO disclosed
US-20050187211-A1 N-arylsalkyl-carboxamide compositions and methods WEI EDWARD T (US) 2005-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050187211-A1 N-arylsalkyl-carboxamide compositions and methods OPRL1, TRPV1, TRPA1 EPHX1 1355/4885TRPM8 13/4885TRPA1 3/4885
US-20240360075-A1 N-SUBSTITUTED C6 CYCLYL CARBOXAMIDE COMPOUNDS AND USES THEREOF TRPM8, TRPM7, TRPM2 EPHX1 2516/4885TRPM8 1/4885TRPA1 9/4885
US-20070155755-A1 N-arylshydroxyalkylidene-carboxamide compositions and methods TRPV1, OPRL1, HRH2 EPHX1 636/4885TRPM8 38/4885TRPA1 5/4885
US-20120184608-A1 N alkylcarbonyl amino lactone compounds and their use TRPA1, TRPV1, TAS2R14 EPHX1 1359/4885TRPM8 21/4885TRPA1 1/4885
US-20080227857-A1 N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use TRPA1, TRPV1, CYSLTR1 EPHX1 1517/4885TRPM8 22/4885TRPA1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.