Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.70 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958539 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| SCHEMBL1150651 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| SCHEMBL10001722 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| SCHEMBL3958542 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| SCHEMBL6128484 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| SCHEMBL10034575 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| SCHEMBL12381602 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| SCHEMBL2637678 | 1.00 | EPHX1 (0.70) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL21331609 | 0.98 | EPHX1 (0.68) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL291654 | 0.98 | EPHX1 (0.68) | EPHX1TRPM8TRPA1SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 756 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121574047-A | Continuous flow preparation method of menthyl formic acid | 安徽丰乐香料有限责任公司 | 2026-02-27 | — | — | CN | claimed |
| CN-119930456-A | Method for preparing N-ethyl-L-menthyl formamide by continuous flow technology | 安徽科芯微流化工科技有限公司 | 2025-05-06 | — | — | CN | claimed |
| US-20250108023-A1 | Products for Masking Bitterness | The Third People's Hospital of Henan Province (CN) | 2025-04-03 | — | — | US | claimed |
| CN-119345083-A | Formula and preparation method of medlar fluffy hair washing cream free of irritation and capable of controlling cooling oil | 宁夏贵合源生物科技发展有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-117945886-B | Synthesis method of WS series cooling agent key intermediate menthyl formic acid | 江苏宏邦化工科技有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-119080629-A | Menthol amide cooling agent WS-5 and preparation method thereof | 辽宁友之泰医药科技有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-115806481-B | Separation and purification method of L-menthyl formic acid | 安徽丰乐香料有限责任公司 | 2024-11-22 | — | — | CN | claimed |
| CN-118829416-A | Composition (III) | 西姆莱斯股份公司 | 2024-10-22 | — | — | CN | claimed |
| CN-117945886-A | Synthesis method of WS series cooling agent key intermediate menthyl formic acid | 江苏宏邦化工科技有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-117813077-A | Composition and method for producing the same | 西姆莱斯股份公司 | 2024-04-02 | — | — | CN | claimed |
| US-20060116277-A1 | Method for the preparation of high-content NaY molecular sieves synthesized from kaolin sprayed microspheres | PETROCHINA COMPANY LIMITED | 2006-06-01 | — | — | US | claimed |
| EP-1656144-A2 | TRP-P8 ACTIVE COMPOUNDS AND THERAPEUTIC TREATMENT METHODS | Genentech, Inc. (US) | 2006-05-17 | — | — | EP | claimed |
| WO-2005117811-A2 | PHYSIOLOGICAL COOLING COMPOSITIONS | MILLENNIUM SPECIALTY CHEMICALS (US) | 2005-12-15 | — | — | WO | claimed |
| US-20050265930-A1 | Physiological cooling compositions | RENESSENZ LLC | 2005-12-01 | — | — | US | claimed |
| WO-2005097735-A1 | PHYSIOLOGICAL COOLING COMPOSITIONS CONTAINING HIGHLY PURIFIED ETHYL ESTER OF N-[[5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL)CARBONYL]GLYCINE | MILLENNIUM SPECIALTY CHEMICALS (US) | 2005-10-20 | — | — | WO | claimed |
| US-20050222256-A1 | Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl)cyclohexyl] carbonyl]glycine | PINOVA HOLDINGS, INC | 2005-10-06 | — | — | US | claimed |
| US-20050159394-A1 | Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets | WEI EDWARD T (US) | 2005-07-21 | — | — | US | claimed |
| US-20050090514-A1 | Trp-p8 active compounds and therapeutic treatment methods | GENENTECH, INC. | 2005-04-28 | — | — | US | claimed |
| WO-2005002582-A2 | TRP-P8 ACTIVE COMPOUNDS AND THERAPEUTIC TREATMENT METHODS | GENENTECH, INC. (US) | 2005-01-13 | — | — | WO | claimed |
| US-4157384-A | Compositions having a physiological cooling effect | WILKINSON SWORD LIMITED (GB) | 1979-06-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050265930-A1 | Physiological cooling compositions | LDHA, HADHA, PC | EPHX1 1239/4885TRPM8 119/4885TRPA1 751/4885 |
| US-20050222256-A1 | Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl)cyclohexyl] carbonyl]glycine | GNMT, GLS, GPR18 | EPHX1 697/4885TRPM8 528/4885TRPA1 1529/4885 |
| US-20050090514-A1 | Trp-p8 active compounds and therapeutic treatment methods | TSG101, TP53, BAX | EPHX1 1033/4885TRPM8 28/4885TRPA1 80/4885 |
| US-20050159394-A1 | Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets | OPRL1, OPRK1, OPRD1 | EPHX1 3744/4885TRPM8 588/4885TRPA1 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.