Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.40 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.40 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11430385 | 0.85 | POLB (0.48) | ITGB1ITGA4F2POLBKDM4E | |
| SCHEMBL11519144 | 0.80 | FKBP5 (0.44) | F2POLBKDM4EMAPTPEPD | |
| SCHEMBL11516346 | 0.80 | FKBP5 (0.44) | F2KDM4EMAPTPEPDFKBP5 | |
| SCHEMBL11517747 | 0.79 | FKBP5 (0.43) | F2POLBKDM4EMAPTPEPD | |
| SCHEMBL10954689 | 0.78 | XIAP (0.46) | F2KDM4EMAPTPEPDFKBP5 | |
| SCHEMBL11517692 | 0.78 | FKBP5 (0.47) | POLBFKBP5 | |
| SCHEMBL11518286 | 0.77 | ACE (0.44) | POLBSMN1; SMN2FKBP5 | |
| SCHEMBL11518459 | 0.76 | NPSR1 (0.47) | ALDH1A1MAPTFKBP5 | |
| SCHEMBL11517312 | 0.73 | PREP (0.62) | — | |
| Bromide SCHEMBL11515540 | 0.73 | DPP4 (0.49) | F2KDM4EMAPTPEPDFKBP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | claimed |
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | disclosed |