Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 8/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3214630 | 1.00 | FFAR1 (0.58) | FFAR1MAOBMAOAADAM17S1PR1 | |
| SCHEMBL1151924 | 1.00 | FFAR1 (0.58) | FFAR1MAOBMAOAADAM17S1PR1 | |
| SCHEMBL1151128 | 0.91 | FFAR1 (0.58) | FFAR1MAOBMAOAS1PR1HTR2A | |
| SCHEMBL1152037 | 0.85 | FFAR1 (0.61) | FFAR1MAOBMAOAS1PR1HTR2A | |
| SCHEMBL2997768 | 0.84 | ALDH1A1 (0.44) | FFAR1MAOBMAOAADAM17MRGPRX4 | |
| SCHEMBL3208841 | 0.83 | FFAR1 (0.54) | FFAR1MAOBMAOAADAM17S1PR1 | |
| SCHEMBL3208831 | 0.83 | FFAR1 (0.54) | FFAR1MAOBMAOAADAM17S1PR1 | |
| SCHEMBL5092413 | 0.80 | FFAR1 (0.61) | FFAR1MAOBMAOARXRARXRB | |
| SCHEMBL7444074 | 0.80 | LTA4H (0.62) | FFAR1MAOB | |
| SCHEMBL10603321 | 0.80 | LTA4H (0.62) | FFAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262364-B1 | OXADIAZOANTHRACENE COMPOUNDS FOR THE TREATMENT OF DIABETES | VTV THERAPEUTICS LLC (US) | 2016-03-02 | — | — | EP | disclosed |
| US-20160002142-A1 | PHENYLGLYOXYLIC ACID DERIVATIVES AND THEIR PREPARATION AND USE | TRANSTECH PHARMA, INC. | 2016-01-07 | — | — | US | disclosed |
| US-9162963-B2 | Phenylglyoxylic acid derivatives and their preparation and use | VTV THERAPEUTICS LLC (US) | 2015-10-20 | — | — | US | disclosed |
| US-9120813-B2 | Oxadiazoanthracene compounds for the treatment of diabetes | VTV THERAPEUTICS LLC (US) | 2015-09-01 | — | — | US | disclosed |
| US-20150087640-A1 | Oxadiazoanthracene Compounds for the Treatment of Diabetes | VTV THERAPEUTICS LLC | 2015-03-26 | — | — | US | disclosed |
| US-8933222-B2 | Oxadiazoanthracene compounds for the treatment of diabetes | TRANSTECH PHARMA, LLC (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140187769-A1 | Oxadiazoanthracene Compounds for the Treatment of Diabetes | TRANSTECH PHARMA, LLC (US) | 2014-07-03 | — | — | US | disclosed |
| US-8703766-B2 | Oxadiazoanthracene compounds for the treatment of diabetes | TRANSTECH PHARMA, LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20130317015-A1 | OXADIAZOANTHRACENE COMPOUNDS FOR THE TREATMENT OF DIABETES | TRANSTECH PHARMA, INC. (US) | 2013-11-28 | — | — | US | disclosed |
| US-20130296599-A1 | PHENYLGLYOXYLIC ACID DERIVATIVES AND THEIR PREPARATION AND USE | VTV THERAPEUTICS LLC | 2013-11-07 | — | — | US | disclosed |
| US-20100197677-A1 | OXADIAZOANTHRACENE COMPOUNDS FOR THE TREATMENT OF DIABETES | TRANSTECH PHARMA, INC. (US) | 2010-08-05 | — | — | US | disclosed |
| US-7727983-B2 | Glucagon-like peptide-1 (GLP-1) receptor modulators such as (S)-2-({(S)-6-Benzoyl-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2-oxo-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl}-amino)-3-(4'-cyano-biphenyl-4-yl)-propionic acid, used as antidiabetic agents; bioavailability | TRANSTECH PHARMA, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20100036150-A1 | MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF | TRANSTECH PHARMA, INC. | 2010-02-11 | — | — | US | disclosed |
| US-20100036150-A1 | MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF | TRANSTECH PHARMA, INC. | 2010-02-11 | — | — | US | disclosed |
| US-20100036150-A1 | MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF | TRANSTECH PHARMA, INC. | 2010-02-11 | — | — | US | disclosed |
| US-20090306063-A1 | Glucagon-like peptide-1 (GLP-1) receptor modulators such as (S)-2-({(S)-6-Benzoyl-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2-oxo-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl}-amino)-3-(4'-cyano-biphenyl-4-yl)-propionic acid, used as antidiabetic agents; bioavailability | TRANS TECH. PHARMA. INC. (US) | 2009-12-10 | — | — | US | disclosed |
| WO-2009111700-A2 | OXADIAZOANTHRACENE COMPOUNDS FOR THE TREATMENT OF DIABETES | TRANSTECH PHARMA, INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| EP-2077987-A1 | MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF | Transtech Pharma, Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051563-A1 | MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF | TRANSTECH PHARMA, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008051563-A1 | MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF | TRANSTECH PHARMA, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002142-A1 | PHENYLGLYOXYLIC ACID DERIVATIVES AND THEIR PREPARATION AND USE | HPD, GRHPR, AGXT | FFAR1 1702/4885MAOB 694/4885MAOA 397/4885 |
| US-20140187769-A1 | Oxadiazoanthracene Compounds for the Treatment of Diabetes | GLP1R, INSR, GPR119 | FFAR1 169/4885MAOB 404/4885MAOA 767/4885 |
| US-20090306063-A1 | Glucagon-like peptide-1 (GLP-1) receptor modulators such as (S)-2-({(S)-6-Benzoyl-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2-oxo-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl}-amino)-3-(4'-cyano-biphenyl-4-yl)-propionic acid, used as antidiabetic agents; bioavailability | GLP1R, GIPR, GCGR | FFAR1 10/4885MAOB 2254/4885MAOA 2685/4885 |
| US-20100197677-A1 | OXADIAZOANTHRACENE COMPOUNDS FOR THE TREATMENT OF DIABETES | GLP1R, GPR119, OTC | FFAR1 339/4885MAOB 259/4885MAOA 696/4885 |
| US-20130296599-A1 | PHENYLGLYOXYLIC ACID DERIVATIVES AND THEIR PREPARATION AND USE | HPD, GRHPR, AGXT | FFAR1 1702/4885MAOB 694/4885MAOA 397/4885 |
| US-20130317015-A1 | OXADIAZOANTHRACENE COMPOUNDS FOR THE TREATMENT OF DIABETES | GLP1R, GPR119, OTC | FFAR1 264/4885MAOB 194/4885MAOA 649/4885 |
| US-20100036150-A1 | MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF | CYP8B1, CYP51A1, COMT | FFAR1 1313/4885MAOB 85/4885MAOA 56/4885 |
| US-20150087640-A1 | Oxadiazoanthracene Compounds for the Treatment of Diabetes | GLP1R, GPR119, OTC | FFAR1 264/4885MAOB 194/4885MAOA 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.