Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 4/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.35 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.35 |
| ▸ | TST | Q16762 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592127 | 0.88 | NR4A1 (0.46) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL30538112 | 0.88 | THRB (0.43) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL29557352 | 0.88 | NR4A1 (0.46) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL31441383 | 0.88 | NR4A1 (0.46) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL11528720 | 0.86 | THRB (0.42) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL2981531 | 0.85 | NR4A1 (0.47) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL4886563 | 0.85 | NR4A1 (0.51) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL9118676 | 0.82 | NR1I2 (0.40) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL18315989 | 0.80 | THRB (0.41) | NR4A1THRBHSPD1HSPE1TST | |
| SCHEMBL27823784 | 0.80 | CTRB1 (0.44) | NR4A1THRBHPGDHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136229-A | SECURITY PAPER | SOCIETE ANONYME DITE: ARJOMARI-PRIOUX (FR) | 1979-01-23 | — | — | US | disclosed |