Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194405 | 0.75 | TGFBR1 (0.39) | TGFBR1ALDH1A1TDP1KDM4E | |
| SCHEMBL463470 | 0.75 | TGFBR1 (0.39) | TGFBR1ALDH1A1TDP1KDM4E | |
| Potassium Ion SCHEMBL502348 | 0.74 | — | — | |
| SCHEMBL4422753 | 0.73 | TDP1 (0.39) | TGFBR1ALDH1A1TDP1KDM4E | |
| SCHEMBL28915783 | 0.73 | TGFBR1 (0.38) | TGFBR1ALDH1A1TDP1KDM4E | |
| Ammonia Solution, Strong SCHEMBL29930752 | 0.73 | TGFBR1 (0.38) | TGFBR1ALDH1A1TDP1KDM4E | |
| SCHEMBL11546233 | 0.73 | TGFBR1 (0.38) | TGFBR1ALDH1A1TDP1KDM4E | |
| SCHEMBL195115 | 0.71 | TGFBR1 (0.41) | TGFBR1ALDH1A1TDP1KDM4E | |
| Potassium Ion SCHEMBL5244880 | 0.71 | TGFBR1 (0.37) | TGFBR1ALDH1A1 | |
| Methacrylic Acid SCHEMBL9986600 | 0.70 | TGFBR1 (0.39) | TGFBR1ALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4164482-A | ORGANIC POLYMER EPITACTICALLY LINKED TO INORGANIC ABSORBENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-08-14 | — | — | US | disclosed |