Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.51 |
| ▸ | MYLK | Q15746 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CLPP | Q16740 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3524088 | 0.84 | LMNA (0.47) | AKT1MYLKMAPK14C5AR1MEN1 | |
| SCHEMBL115542 | 0.82 | LMNA (0.50) | AKT1MYLKMAPK14C5AR1MEN1 | |
| SCHEMBL116437 | 0.82 | ALDH1A1 (0.51) | AKT1MYLKMAPK14C5AR1MEN1 | |
| SCHEMBL16104427 | 0.80 | C5AR1 (0.54) | AKT1MYLKMAPK14C5AR1MEN1 | |
| SCHEMBL116629 | 0.79 | LMNA (0.47) | AKT1MYLKMAPK14C5AR1MEN1 | |
| SCHEMBL3434578 | 0.79 | ALDH1A1 (0.47) | AKT1MYLKMAPK14C5AR1CFTR | |
| SCHEMBL115476 | 0.78 | KMT2A (0.57) | C5AR1MEN1KMT2ACLPP | |
| SCHEMBL9659792 | 0.77 | CLPP (0.52) | AKT1MYLKMAPK14C5AR1MEN1 | |
| SCHEMBL3434587 | 0.76 | ALDH1A1 (0.58) | AKT1MYLKMAPK14CFTRMEN1 | |
| SCHEMBL167919 | 0.76 | LMNA (0.46) | AKT1MYLKMAPK14C5AR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424532-B1 | COMPOUNDS FOR INDUCING CELLULAR APOPTOSIS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2014-09-24 | — | — | EP | disclosed |
| US-8716302-B2 | Compounds for inducing cellular apoptosis | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2014-05-06 | — | — | US | disclosed |
| EP-2424532-A1 | COMPOUNDS FOR INDUCING CELLULAR APOPTOSIS | Queen Mary and Westfield College (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125343-A1 | COMPOUNDS FOR INDUCING CELLULAR APOPTOSIS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2010-11-04 | — | — | WO | disclosed |