Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4987941 | 0.77 | ACHE (0.57) | NAAAACHEBACE1SIGMAR1BCHE | |
| SCHEMBL4935312 | 0.74 | BCHE (0.59) | NAAAACHEBACE1BCHE | |
| SCHEMBL27525298 | 0.69 | NAAA (0.58) | NAAAACHESIGMAR1 | |
| SCHEMBL2885978 | 0.69 | SIGMAR1 (0.54) | ACHEGBA1SIGMAR1 | |
| SCHEMBL8301747 | 0.66 | HTR1A (0.51) | ACHEGBA1SIGMAR1 | |
| SCHEMBL3176956 | 0.66 | HTR1A (0.51) | ACHEGBA1SIGMAR1 | |
| SCHEMBL10921182 | 0.64 | GBA1 (0.45) | ACHEGBA1SIGMAR1 | |
| SCHEMBL9595473 | 0.64 | SIGMAR1 (0.50) | ACHEGBA1SIGMAR1 | |
| SCHEMBL31175320 | 0.64 | SIGMAR1 (0.45) | NAAAGBA1SIGMAR1 | |
| SCHEMBL7575349 | 0.63 | GBA1 (0.47) | ACHEGBA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005318-A1 | N-Heterocyclyl-4-piperidinamines, methods for their preparation, pharmaceutical compositions comprising them, intermediates therefor, and method for the preparation of the intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-14 | — | — | EP | disclosed |