SCHEMBL11599743

SCHEMBL11599743

CP(=O)(O)Oc1ccc(C#N)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
MAPT P10636 2/20 0.45
ALDH1A1 P00352 2/20 0.45
MMP2 P08253 3/20 0.44
PARP15 Q460N3 1/20 0.43
PARP10 Q53GL7 1/20 0.43
PARP2 Q9UGN5 1/20 0.43
CA2 P00918 3/20 0.43
CA9 Q16790 2/20 0.43
CA1 P00915 2/20 0.43
RAB9A P51151 2/20 0.42
KMT2A Q03164 2/20 0.42
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 1/20 0.42
LMNA P02545 1/20 0.42
POLB P06746 1/20 0.42
PKM P14618 1/20 0.42
MAPK1 P28482 1/20 0.42
IL18 Q14116 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17512951 0.84 CES2 (0.48) MAPTALDH1A1MMP2PARP15PARP10
SCHEMBL28757584 0.84 CA2 (0.46) MAPTALDH1A1MMP2PARP15PARP10
SCHEMBL8055795 0.84 SRC (0.54) MAPTALDH1A1MMP2PARP15PARP10
SCHEMBL2169863 0.83 CYP2C19 (0.69) CYP2C19SMN1; SMN2CA2CA1KMT2A
SCHEMBL2354336 0.81 MMP2 (0.44) MAPTALDH1A1MMP2PARP15PARP10
SCHEMBL572710 0.79 TSHR (0.52) MAPTALDH1A1MMP2PARP15PARP10
SCHEMBL10814636 0.77 CYP2C19 (0.62) CYP2C19SMN1; SMN2CA2CA1KMT2A
Cyanophos-Oxon SCHEMBL17445283 0.77 CYP3A4 (0.45) MAPTALDH1A1MMP2PARP15PARP10
SCHEMBL2354339 0.76 CA2 (0.43) MAPTALDH1A1MMP2PARP15PARP10
SCHEMBL14095661 0.76 ALDH1A1 (0.43) MAPTALDH1A1PARP15PARP10PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1835934-A oxazole derivatives as cyclooxygenase inhibitors ASTELLAS PHARMA INC (JP) 2006-09-20 CN disclosed
US-4073894-A INSECTICIDES VELSICOL CHEMICAL CORPORATION (US) 1978-02-14 US disclosed