Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | NQO2 | P16083 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine SCHEMBL2923781 | 1.00 | MAPT (0.65) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Phenazine SCHEMBL28835271 | 0.97 | MAPT (0.61) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Phenazine SCHEMBL23522712 | 0.89 | MAPT (0.58) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Phenazine SCHEMBL1750964 | 0.89 | MAPT (0.58) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Phenazine SCHEMBL23522711 | 0.89 | MAPT (0.58) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Phenazine SCHEMBL28366239 | 0.87 | MAPT (0.55) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Phenazine SCHEMBL22631548 | 0.87 | MAPT (0.55) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Phenazine SCHEMBL28658053 | 0.87 | MAPT (0.55) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Acridine SCHEMBL10831095 | 0.85 | ALDH1A1 (0.71) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 | |
| Acridine SCHEMBL11600717 | 0.85 | ALDH1A1 (0.71) | MAPTALDH1A1NQO2SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180180587-A1 | PAPER MICROFLUIDIC DEVICES FOR DETECTION OF IMPROVISED EXPLOSIVES | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-06-28 | — | — | US | claimed |
| US-9891207-B2 | Paper microfluidic devices for detection of improvised explosives | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-02-13 | — | — | US | claimed |
| US-20160139102-A1 | PAPER MICROFLUIDIC DEVICES FOR DETECTION OF IMPROVISED EXPLOSIVES | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-05-19 | — | — | US | claimed |
| EP-4018791-A1 | METHOD OF PREPARING A HIGH DENSITY INTERCONNECT PRINTED CIRCUIT BOARD INCLUDING MICROVIAS FILLED WITH COPPER | Atotech Deutschland GmbH & Co. KG (DE) | 2022-06-29 | — | — | EP | disclosed |
| EP-2619244-B1 | IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS | MACDERMID ACUMEN INC (US) | 2018-11-14 | — | — | EP | disclosed |
| US-10036738-B2 | Paper microfluidic devices for detection of improvised explosives | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-07-31 | — | — | US | disclosed |
| US-20180180587-A1 | PAPER MICROFLUIDIC DEVICES FOR DETECTION OF IMPROVISED EXPLOSIVES | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-06-28 | — | — | US | disclosed |
| US-9891207-B2 | Paper microfluidic devices for detection of improvised explosives | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-02-13 | — | — | US | disclosed |
| US-20160139102-A1 | PAPER MICROFLUIDIC DEVICES FOR DETECTION OF IMPROVISED EXPLOSIVES | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-05-19 | — | — | US | disclosed |
| US-5849171-A | Acid bath for copper plating and process with the use of this combination | ATOTECH DEUTSCHLAND GMBH (DE) | 1998-12-15 | — | — | US | disclosed |
| US-5334508-A | A mixture reagent consisting of an oxidoreductase enzyme, an aromatic nitroso or a oxime compound and a couplers; free of reducing catalysts, side-effect reduction | BOEHRINGER MANNHEIM GMBH (DE) | 1994-08-02 | — | — | US | disclosed |
| US-5206147-A | COLORIMETRIC ASSAY BY ENZYMATIC OXIDATION IN THE PRESENCE OF AN AROMATIC NITROSO OR OXIME COMPOUND | BOEHRINGER MANNHEIM GMBH (DE) | 1993-04-27 | — | — | US | disclosed |