Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11612175 | 0.78 | KMT2A (0.45) | CYP1A2CYP2C9MAPTNPC1POLB | |
| SCHEMBL11612313 | 0.73 | HPGD (0.48) | LMNACYP1A2CYP2C9MAPTPOLB | |
| SCHEMBL11613221 | 0.73 | MAPT (0.44) | LMNACYP1A2TSHRMAPTNPC1 | |
| SCHEMBL11617777 | 0.71 | PTGER4 (0.41) | LMNACYP1A2CYP2C9MAPTPOLB | |
| SCHEMBL11613046 | 0.68 | NPC1 (0.43) | LMNACYP2C19TSHRNPC1SMN1; SMN2 | |
| SCHEMBL11616262 | 0.65 | PTGDR2 (0.47) | LMNAPOLBSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8407977 | 0.65 | LMNA (0.62) | LMNACYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL11611124 | 0.65 | NPC1 (0.47) | LMNACYP2C19NPC1SMN1; SMN2KMT2A | |
| SCHEMBL11616738 | 0.65 | MAPK1 (0.45) | LMNAMAPTKMT2AALDH1A1HPGD | |
| SCHEMBL11615339 | 0.65 | KMT2A (0.49) | CYP1A2CYP2C9CYP2C19MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |