SCHEMBL11697332

SCHEMBL11697332

COc1cc(Br)c2n[c]sc2c1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
GRM2 Q14416 1/20 0.34
PRNP P04156 1/20 0.30
MAPT P10636 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C19 P33261 1/20 0.30
NQO2 P16083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11698158 0.83 MAPT (0.37) ALDH1A1MAPTCYP3A4
SCHEMBL7577367 0.82 LMNA (0.37) ALDH1A1CYP1A2CYP3A4
SCHEMBL8390408 0.77 NQO2 (0.33) ALDH1A1PRNPMAPTNPSR1RXFP1
SCHEMBL11699435 0.71 NPC1 (0.32)
SCHEMBL5003712 0.70
SCHEMBL533470 0.69 CYP1A2 (0.49) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL9007911 0.67 MTNR1A (0.38) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL10971640 0.67 CYP3A4 (0.54) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL2160767 0.66 RAB9A (0.43) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL7574867 0.65 ALDH1A1 (0.38) ALDH1A1MAPTRXFP1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4022762-A Water-soluble acid azo dyestuff containing a N-(p-sulphophenoxyalkyl)-N-alkyl amino group PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-05-10 US claimed
US-4022762-A Water-soluble acid azo dyestuff containing a N-(p-sulphophenoxyalkyl)-N-alkyl amino group PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-05-10 US disclosed
US-4022762-A Water-soluble acid azo dyestuff containing a N-(p-sulphophenoxyalkyl)-N-alkyl amino group PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-05-10 US disclosed