Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11843293 | 0.78 | SIGMAR1 (0.44) | SIGMAR1HTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL11737034 | 0.72 | RAB9A (0.35) | SIGMAR1ALDH1A1HTR1ANPC1RAB9A | |
| SCHEMBL11684159 | 0.68 | SIGMAR1 (0.44) | SIGMAR1HTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL11853705 | 0.68 | SIGMAR1 (0.49) | SIGMAR1ADRA2A | |
| SCHEMBL14529908 | 0.67 | SIGMAR1 (0.48) | SIGMAR1HTR2CHTR2BALDH1A1ADRB2 | |
| SCHEMBL3026877 | 0.63 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL28608827 | 0.61 | SIGMAR1 (0.39) | SIGMAR1HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL11684464 | 0.61 | PRCP (0.39) | HTR7 | |
| SCHEMBL25356724 | 0.61 | CCR2 (0.43) | SIGMAR1HTR2CHTR2BHTR2AADRA2A | |
| SCHEMBL736532 | 0.61 | AVPR1A (0.53) | SIGMAR1HTR2CHTR2BHTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031224-A | 1,3-Dihydro-heteroarylspiro (isobenzofuran)s | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |