Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11843293 | 0.90 | SIGMAR1 (0.44) | SIGMAR1HTR2COPRD1KCNH2SLC6A2 | |
| SCHEMBL11853705 | 0.85 | SIGMAR1 (0.49) | SIGMAR1OPRD1KCNH2 | |
| SCHEMBL11680301 | 0.83 | OPRD1 (0.43) | SIGMAR1OPRD1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL11783954 | 0.81 | DRD2 (0.41) | SIGMAR1OPRD1KCNH2 | |
| SCHEMBL29705809 | 0.80 | OPRD1 (0.50) | SIGMAR1OPRD1KCNH2 | |
| SCHEMBL4363631 | 0.80 | OPRD1 (0.50) | SIGMAR1OPRD1KCNH2 | |
| SCHEMBL11781081 | 0.78 | PRCP (0.42) | SIGMAR1OPRD1KCNH2KDM4EKMT2A | |
| SCHEMBL11852054 | 0.78 | PRCP (0.42) | SIGMAR1OPRD1KCNH2HTR2A | |
| SCHEMBL11683068 | 0.77 | ALDH1A1 (0.40) | OPRD1KCNH2KDM4E | |
| SCHEMBL11860134 | 0.74 | PRCP (0.52) | SIGMAR1OPRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3959475-A | ANTIDEPRESSANT, TRANQUILIZER, ANALGESIC | AMERICAN HOECHST CORPORATION (US) | 1976-05-25 | — | — | US | claimed |
| US-4024263-A | ANALGESIC, ANTICONVULSANT, ANTIDEPRESSANT | AMERICAN HOECHST CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3996354-A | 1,3-Dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro(isobenzofuran)s | AMERICAN HOECHST CORPORATION (US) | 1976-12-07 | — | — | US | disclosed |
| US-3959475-A | ANTIDEPRESSANT, TRANQUILIZER, ANALGESIC | AMERICAN HOECHST CORPORATION (US) | 1976-05-25 | — | — | US | disclosed |