Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 4/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11745099 | 0.88 | SKP2 (0.46) | NPC1RAB9ATP53PKMSMN1; SMN2 | |
| SCHEMBL10399428 | 0.83 | NOS3 (0.42) | NPC1RAB9ATP53PKMSMN1; SMN2 | |
| SCHEMBL5037010 | 0.76 | MAOA (0.52) | SMN1; SMN2NOS1 | |
| SCHEMBL712018 | 0.76 | CA2 (0.34) | — | |
| SCHEMBL24869145 | 0.76 | NPC1 (0.39) | NPC1RAB9ATP53PKMSMN1; SMN2 | |
| SCHEMBL5036417 | 0.73 | CPB2 (0.36) | NOS2NOS3NOS1GABRA1GABRB2 | |
| SCHEMBL6615395 | 0.73 | NPC1 (0.41) | NPC1RAB9ATP53PKMSMN1; SMN2 | |
| SCHEMBL10401174 | 0.71 | SKP2 (0.49) | NPC1RAB9ATP53PKMSMN1; SMN2 | |
| SCHEMBL19150756 | 0.69 | TLR8 (0.50) | RAB9ASMN1; SMN2HSD17B10MAPTTLR8 | |
| SCHEMBL21988090 | 0.69 | RAB9A (0.40) | NPC1RAB9ATP53PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4002761-A | ANTHELMINTIC AGENTS, FUNGICIDAL AGENTS | SMITHKLINE CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |
| US-4000285-A | ANTHELMINTICS | SMITHKLINE CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |
| US-3961063-A | ANTHELMINTICS | SMITHKLINE CORPORATION (US) | 1976-06-01 | — | — | US | disclosed |