Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 7/20 | 0.65 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143769 | 0.80 | FDPS (1.00) | FDPSLMNAGRM4ADRB3PDE4D | |
| Ethane SCHEMBL11407880 | 0.77 | FDPS (0.93) | FDPSLMNAGRM4ADRB3PDE4D | |
| SCHEMBL10946360 | 0.77 | FDPS (0.93) | FDPSLMNAGRM4ADRB3PDE4D | |
| SCHEMBL11585006 | 0.75 | FDPS (0.43) | FDPS | |
| SCHEMBL11585012 | 0.75 | FDPS (0.43) | FDPS | |
| Tert-Butylamine SCHEMBL5573000 | 0.71 | FDPS (0.53) | FDPSSLC34A1LMNAGRM4GGPS1 | |
| Etidronic Acid SCHEMBL20292490 | 0.70 | LMNA (0.63) | FDPSSLC34A1LMNAGGPS1KDM4E | |
| Butane SCHEMBL11413820 | 0.70 | FDPS (0.78) | FDPSLMNAGRM4GGPS1ADRB3 | |
| SCHEMBL366377 | 0.70 | — | — | |
| SCHEMBL5355267 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4025616-A | Oral compositions for plaque, caries and calculus retardation with reduced staining tendencies | THE PROCTER & GAMBLE COMPANY (US) | 1977-05-24 | — | — | US | disclosed |
| US-3959458-A | PHOSPHONATE OR AMINO-PHOSPHORUS COMPOUND | THE PROCTER & GAMBLE COMPANY (US) | 1976-05-25 | — | — | US | disclosed |
| US-3934002-A | BIS-GUANIDE | THE PROCTER & GAMBLE COMPANY (US) | 1976-01-20 | — | — | US | disclosed |