SCHEMBL11747741

SCHEMBL11747741

COn1c(-c2ccccc2)cc2ccccc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.59
MAOA P21397 3/20 0.57
ALDH1A1 P00352 3/20 0.47
HPGD P15428 3/20 0.47
KDM4E B2RXH2 2/20 0.47
HSD17B10 Q99714 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
BACE1 P56817 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.42
MAOB P27338 1/20 0.42
NPC1 O15118 1/20 0.42
CASP3 P42574 1/20 0.42
RAB9A P51151 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
GRIK1 P39086 1/20 0.42
GRIK2 Q13002 1/20 0.42
MTNR1A P48039 1/20 0.40
MTNR1B P49286 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11745418 0.81 KMT2A (0.54) KMT2AMAOAALDH1A1HPGDKDM4E
SCHEMBL3727104 0.80 KMT2A (0.53) KMT2AMAOAALDH1A1HPGDKDM4E
SCHEMBL5227447 0.78 ALDH1A1 (0.56) KMT2AMAOAALDH1A1HPGDKDM4E
SCHEMBL5373731 0.78 MAOA (0.45) KMT2AMAOA
SCHEMBL6172365 0.76 SMN1; SMN2 (0.55) KMT2AMAOAALDH1A1KDM4EHSD17B10
SCHEMBL670199 0.75 SMN1; SMN2 (0.47) KMT2AALDH1A1KDM4EL3MBTL1BACE1
SCHEMBL214075 0.75 KMT2A (1.00) KMT2AALDH1A1HPGDKDM4EHSD17B10
SCHEMBL29581156 0.75 KMT2A (1.00) KMT2AALDH1A1HPGDKDM4EHSD17B10
SCHEMBL3969742 0.74 SMN1; SMN2 (0.42) KMT2AMAOAKDM4EBACE1SMN1; SMN2
SCHEMBL5201047 0.74 L3MBTL1 (0.50) KMT2AMAOAALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE29168-E HEAT SENSITIVE, ANTIHALATION LAYER EASTMAN KODAK COMPANY (US) 1977-04-05 US disclosed