Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398540 | 0.93 | MAPT (0.53) | ALDH1A1GAAMAPTKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL1177366 | 0.91 | MAPT (0.52) | ALDH1A1GAAMAPTKMT2ALMNA | |
| SCHEMBL1177415 | 0.91 | ALDH1A1 (0.54) | ALDH1A1GAAMAPTKMT2ALMNA | |
| SCHEMBL1177875 | 0.87 | LMNA (0.51) | ALDH1A1MAPTKMT2ALMNACA1 | |
| SCHEMBL1177416 | 0.85 | LMNA (0.48) | ALDH1A1GAAMAPTKMT2ALMNA | |
| SCHEMBL1177280 | 0.85 | IDO1 (0.42) | ALDH1A1GAAMAPTKMT2ALMNA | |
| Chloroacetic Acid SCHEMBL19183007 | 0.85 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTKMT2ALMNA | |
| SCHEMBL1177430 | 0.85 | LMNA (0.62) | ALDH1A1GAAMAPTKMT2ALMNA | |
| Trichloroacetic Acid SCHEMBL19183346 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTKMT2ALMNA | |
| Dichloroacetic Acid SCHEMBL19183184 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8692014-B2 | Acid addition salts of 5-aminolevulinic acid or its derivatives | PHOTOCURE ASA (NO) | 2014-04-08 | — | — | US | disclosed |
| US-20110125012-A1 | ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES | BRAENDEN JON ERIK | 2011-05-26 | — | — | US | disclosed |
| EP-2308830-A1 | Acid addition salts of 5-aminolevulinic acid or its derivatives | Photocure ASA (NO) | 2011-04-13 | — | — | EP | disclosed |
| US-7888526-B2 | Nonhygroscopic photosensitizing agents; sulphonate, hydrobromide, sulfate, nitrate and/or phosphate derivatives; diagnosing skin disorders | PHOTOCURE ASA (NO) | 2011-02-15 | — | — | US | disclosed |
| US-20080064752-A1 | Acid Addition Salts Of-5-Aminolevulinic Acid Or Its Derivatives | PHOTOCURE ASA (NO) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064752-A1 | Acid Addition Salts Of-5-Aminolevulinic Acid Or Its Derivatives | ALAD, AASDHPPT, ABAT | HTR2C 2044/4885ALDH1A1 793/4885GAA 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.