Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11815385 | 0.88 | MRGPRX4 (0.46) | MRGPRX4MEN1KMT2AEPHX1AURKA | |
| SCHEMBL11820227 | 0.85 | TRPV1 (0.46) | MRGPRX4MEN1KMT2AAURKATPX2 | |
| SCHEMBL11818108 | 0.85 | PTPRZ1 (0.40) | MRGPRX4MEN1KMT2AEPHX1AURKA | |
| SCHEMBL11818815 | 0.84 | MRGPRX4 (0.42) | MRGPRX4MEN1KMT2AEPHX1AURKA | |
| SCHEMBL11817074 | 0.84 | DAO (0.41) | MRGPRX4AURKATPX2PPARAPPARG | |
| SCHEMBL11820578 | 0.80 | ALDH1A1 (0.45) | MRGPRX4MEN1KMT2ARXRARXRB | |
| SCHEMBL24017339 | 0.76 | KCNK2 (0.48) | MRGPRX4MEN1KMT2AAURKATPX2 | |
| SCHEMBL11823334 | 0.75 | MCL1 (0.44) | MEN1KMT2AHPGDLMNACXCR2 | |
| SCHEMBL31550001 | 0.74 | AURKA (0.56) | MRGPRX4MEN1KMT2AAURKATPX2 | |
| SCHEMBL475754 | 0.74 | AURKA (0.56) | MRGPRX4MEN1KMT2AAURKATPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3954994-A | Intermediates for preparing hipolipemic agents and method of lowering the blood lipid level in mammals with said agents | PFIZER INC. (US) | 1976-05-04 | — | — | US | disclosed |