SCHEMBL11893156

SCHEMBL11893156

Cc1cc(C#N)cc(C(=O)NC(C)(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 5/20 0.37
SLC2A3 P11169 5/20 0.37
SLC2A4 P14672 5/20 0.37
SLC2A2 P11168 2/20 0.37
PDE4B Q07343 1/20 0.36
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
KLKB1 P03952 9/20 0.35
F2 P00734 1/20 0.34
F10 P00742 1/20 0.34
TRPV1 Q8NER1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL782240 0.92 SLC2A1 (0.38) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B
SCHEMBL31059991 0.90 SLC2A1 (0.42) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B
SCHEMBL960289 0.90 SLC2A1 (0.42) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B
SCHEMBL10028761 0.90 KDM4E (0.37) PDE4BKMT2AKDM4EMEN1ALDH1A1
SCHEMBL782144 0.90 KLKB1 (0.37) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B
SCHEMBL10028765 0.89 DHODH (0.36) PDE4BKMT2AKDM4EMEN1ALDH1A1
SCHEMBL5620493 0.89 SLC2A1 (0.36) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B
SCHEMBL10118298 0.89 OPRL1 (0.35) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B
SCHEMBL12870073 0.89 SLC2A1 (0.35) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B
SCHEMBL12117033 0.87 SLC2A1 (0.40) SLC2A1SLC2A3SLC2A4SLC2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993480-B2 Active ingredient combinations with insecticidal properties BAYER CROPSCIENCE AG (DE) 2015-03-31 US disclosed
US-8298989-B2 Active ingredient combinations with insecticidal properties BAYER CROPSCIENCE AG (DE) 2012-10-30 US disclosed
US-20120190544-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES BAYER CROPSCIENCE AG (DE) 2012-07-26 US disclosed
US-7977278-B2 Suspension concentrates BAYER CROPSCIENCE AG (DE) 2011-07-12 US disclosed
US-20100099717-A1 SUSPENSION CONCENTRATES FOR IMPROVING THE ROOT ABSORPTION OF AGROCHEMICAL ACTIVE INGREDIENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-04-22 US disclosed
US-20100010051-A1 SUSPENSION CONCENTRATES BAYER CROPSCIENCE AG (DE) 2010-01-14 US disclosed
US-20090306147-A1 BIOLOGICAL EFFICACY OF AGROCHEMICAL COMPOSITIONS ON APPLICATION IN THE GROWTH SUBSTRATE SUITABLE FORMULATIONS AND USE THEREOF BAYER CROPSCIENCE AG (DE) 2009-12-10 US disclosed
US-20090275471-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES BAYER CROPSCIENCE AG (DE) 2009-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100099717-A1 SUSPENSION CONCENTRATES FOR IMPROVING THE ROOT ABSORPTION OF AGROCHEMICAL ACTIVE INGREDIENTS CROCC, SLC19A1, ABCB11 SLC2A1 45/4885SLC2A3 73/4885SLC2A4 97/4885
US-20120190544-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES AADAC, ACHE, NAAA SLC2A1 4748/4885SLC2A3 4604/4885SLC2A4 4709/4885
US-20100010051-A1 SUSPENSION CONCENTRATES AKR7A2, CBR3, DCXR SLC2A1 3684/4885SLC2A3 3546/4885SLC2A4 3946/4885
US-20090275471-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES AADAC, ACHE, NAAA SLC2A1 4748/4885SLC2A3 4604/4885SLC2A4 4709/4885
US-20090306147-A1 BIOLOGICAL EFFICACY OF AGROCHEMICAL COMPOSITIONS ON APPLICATION IN THE GROWTH SUBSTRATE SUITABLE FORMULATIONS AND USE THEREOF CYP51A1, CYP21A2, CYP4X1 SLC2A1 4237/4885SLC2A3 3348/4885SLC2A4 4104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.