SCHEMBL782144

SCHEMBL782144

Cc1cc(C#N)cc(C(=O)NC(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 9/20 0.37
SLC2A1 P11166 3/20 0.36
SLC2A3 P11169 3/20 0.36
SLC2A4 P14672 3/20 0.36
SLC2A2 P11168 1/20 0.36
PDE4B Q07343 2/20 0.35
GCK P35557 2/20 0.35
KCNH2 Q12809 2/20 0.35
OPRL1 P41146 1/20 0.34
F2 P00734 1/20 0.34
F10 P00742 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10140202 0.94 KLKB1 (0.38) KLKB1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL11893226 0.93 KLKB1 (0.41) KLKB1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL782240 0.91 SLC2A1 (0.38) KLKB1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL672741 0.90 PDE4B (0.36) KLKB1PDE4BF10
SCHEMBL14360665 0.90 KDM4E (0.37) KLKB1PDE4BOPRL1
SCHEMBL11893156 0.90 SLC2A1 (0.37) KLKB1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL14470584 0.90 PDE4B (0.36) KLKB1PDE4BOPRL1
SCHEMBL960289 0.90 SLC2A1 (0.42) KLKB1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL31059991 0.90 SLC2A1 (0.42) KLKB1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL563295 0.90 KCNH2 (0.37) SLC2A1SLC2A3SLC2A4SLC2A2PDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210378242-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2021-12-09 US disclosed
US-10405548-B2 Fungicidal compositions SYNGENTA CROP PROTECTION LLC (US) 2019-09-10 US disclosed
EP-2547665-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-07-04 EP disclosed
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-20170071205-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-03-16 US disclosed
US-20170027173-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, LLC (US) 2017-02-02 US disclosed
US-20170027173-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, LLC (US) 2017-02-02 US disclosed
EP-2723723-B1 N-OXY PYRAZOLO-TRIAZEPINE-DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-02-01 EP disclosed
US-20080182750-A1 Cyano Anthranilamide Insecticides SYNGENTA CROP PROTECTION, INC. (US) 2008-07-31 US disclosed
US-20080146552-A1 Anthranilamide Derivatives as Insecticides SYNGENTA CROP PROTECTION, INC. 2008-06-19 US disclosed
US-20080146552-A1 Anthranilamide Derivatives as Insecticides SYNGENTA CROP PROTECTION, INC. 2008-06-19 US disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
WO-2007093402-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 WO disclosed
WO-2007080131-A2 ANTHRANILAMIDE DERIVATIVES AND THEIR USE FOR THE CONTROL OF INSECTS AND ACARI SYNGENTA PARTICIPATIONS AG (CH) 2007-07-19 WO disclosed
WO-2007068356-A1 INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT BAYER CROPSCIENCE AG (DE) 2007-06-21 WO disclosed
WO-2007020050-A2 BICYCLIC BISAMIDE DERIVATIVES AND USE THEREOF AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-02-22 WO disclosed
WO-2007009661-A2 PESTICIDAL MIXTURES CONTAINING BICYCLIC ANTHRANILAMIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210378242-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 KLKB1 3263/4885SLC2A1 4040/4885SLC2A3 3742/4885
US-20170027173-A1 INSECTICIDAL COMPOUNDS ACHE, AADAC, CASP3 KLKB1 3945/4885SLC2A1 4777/4885SLC2A3 4496/4885
US-20080146552-A1 Anthranilamide Derivatives as Insecticides DDT, ALDH7A1, AADAC KLKB1 4513/4885SLC2A1 4038/4885SLC2A3 4464/4885
US-20070244073-A1 Pesticidal Mixtures ACHE, ATL3, BPHL KLKB1 4646/4885SLC2A1 4394/4885SLC2A3 4206/4885
US-20080182750-A1 Cyano Anthranilamide Insecticides CRY1, CRYAA, ALDH7A1 KLKB1 4334/4885SLC2A1 3493/4885SLC2A3 4368/4885
US-10405548-B2 Fungicidal compositions PIK3C3, CYP51A1, CYP1B1 KLKB1 3263/4885SLC2A1 4040/4885SLC2A3 3742/4885
US-20170071205-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 KLKB1 3263/4885SLC2A1 4040/4885SLC2A3 3742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.