Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 7/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.38 |
| ▸ | WNT1 | P04628 | 4/20 | 0.38 |
| ▸ | ULK1 | O75385 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15219344 | 0.82 | GSK3B (0.42) | SMN1; SMN2GSK3BDYRK1AWNT1ULK1 | |
| SCHEMBL11915928 | 0.80 | FLT3 (0.42) | ALDH1A1SMN1; SMN2GSK3BDYRK1AWNT1 | |
| SCHEMBL30586416 | 0.68 | TP53 (0.49) | ULK1KHKKCNH2 | |
| SCHEMBL13619159 | 0.66 | ULK1 (0.42) | SMN1; SMN2GSK3BDYRK1AWNT1ULK1 | |
| SCHEMBL10197817 | 0.65 | KMT2A (0.61) | ALDH1A1SMN1; SMN2ULK1FLT3 | |
| SCHEMBL1018964 | 0.64 | GNAI3 (0.64) | ALDH1A1SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL11919076 | 0.64 | SIGMAR1 (0.41) | ALDH1A1SMN1; SMN2GSK3BDYRK1AFLT3 | |
| SCHEMBL5190435 | 0.63 | ADORA1 (0.45) | GSK3BDYRK1AWNT1ULK1 | |
| SCHEMBL2322149 | 0.63 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2FLT3EPHX2 | |
| Hydrochloric Acid SCHEMBL6803030 | 0.63 | GNAI3 (0.67) | ALDH1A1SMN1; SMN2GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202776-A1 | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20110288078-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202776-A1 | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS | PHKA1, PIK3CA, PHKA2 | ALDH1A1 4596/4885SMN1; SMN2 4743/4885GNAI3 577/4885 |
| US-20110288078-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | MAP3K5, MAP3K15, MAP4K2 | ALDH1A1 3173/4885SMN1; SMN2 4775/4885GNAI3 537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.