Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12196344 | 0.86 | CES2 (0.55) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL16396412 | 0.83 | RAB9A (0.63) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL1199274 | 0.79 | LMNA (0.47) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL11524668 | 0.79 | MAPT (0.59) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL1245507 | 0.78 | CES2 (0.55) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL181572 | 0.77 | CES2 (0.78) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL8623532 | 0.76 | ALDH1A1 (0.58) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL8962468 | 0.76 | CES2 (0.75) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL1198305 | 0.75 | ALDH1A1 (0.49) | TP53ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL1198618 | 0.74 | RAB9A (0.52) | CES2CES1ALDH1A1TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| EP-1812112-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044753-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143366-A1 | CHEMICAL COMPOUNDS | ROCK2, ROCK1, ABL1 | CES2 1589/4885CES1 3374/4885TP53 3156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.