Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 1.00 |
| ▸ | CCR5 | P51681 | 12/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227220 | 1.00 | KCNH2 (1.00) | KCNH2CCR5 | |
| SCHEMBL1080663 | 1.00 | KCNH2 (1.00) | KCNH2CCR5 | |
| Water SCHEMBL4012865 | 0.99 | KCNH2 (0.99) | KCNH2CCR5 | |
| Water SCHEMBL4012863 | 0.99 | KCNH2 (0.99) | KCNH2CCR5 | |
| Cadaverine Tartrate SCHEMBL5671998 | 0.96 | KCNH2 (0.92) | KCNH2CCR5 | |
| SCHEMBL30227462 | 0.95 | KCNH2 (0.91) | KCNH2CCR5 | |
| SCHEMBL1079565 | 0.95 | KCNH2 (0.91) | KCNH2CCR5 | |
| SCHEMBL1053063 | 0.95 | KCNH2 (0.91) | KCNH2CCR5 | |
| SCHEMBL1198672 | 0.94 | CCR5 (1.00) | KCNH2CCR5 | |
| SCHEMBL1198671 | 0.94 | CCR5 (1.00) | KCNH2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140271680-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PULMONARY HYPERTENSION | UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE (FR) | 2014-09-18 | — | — | US | claimed |
| US-20130039885-A1 | LEUKOTOXIN E/D AS A NEW ANTI-INFLAMMATORY AGENT AND MICROBICIDE | NEW YORK UNIVERSITY (US) | 2013-02-14 | — | — | US | claimed |
| US-20160355528-A1 | INHIBITORS OF HIV REPLICATION | VIIV HEALTHCARE UK LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-9447116-B2 | Inhibitors of HIV replication | VIIV HEALTHCARE UK LIMITED (GB) | 2016-09-20 | — | — | US | disclosed |
| US-20150336965-A1 | NOVEL ANTIVIRAL COMPOUNDS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2015-11-26 | — | — | US | disclosed |
| US-9132129-B2 | Antiviral compounds | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2015-09-15 | — | — | US | disclosed |
| US-20140315927-A1 | Inhibitors of HIV Replication | VIIV HEALTHCARE UK LIMITED (GB) | 2014-10-23 | — | — | US | disclosed |
| US-8846609-B2 | Leukotoxin E/D as a new anti-inflammatory agent and microbicide | NEW YORK UNIVERSITY (US) | 2014-09-30 | — | — | US | disclosed |
| US-8809363-B2 | Inhibitors of HIV replication | VIIV HEALTHCARE UK LIMITED (GB) | 2014-08-19 | — | — | US | disclosed |
| EP-2516008-B1 | NOVEL ANTIVIRAL COMPOUNDS | UNIV LEUVEN KATH (BE) | 2014-04-16 | — | — | EP | disclosed |
| EP-2640729-A1 | INHIBITORS OF HIV REPLICATION | VIIV Healthcare UK Limited (GB) | 2013-09-25 | — | — | EP | disclosed |
| US-7217721-B2 | Tropane derivatives useful in therapy | PFIZER, INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-20070082942-A1 | Prevention of hiv-1 infection by inhibition of rho-mediated reorganization and/or content alteration of cell membrane raft | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS | 2007-04-12 | — | — | US | disclosed |
| US-20060264448-A1 | Purine derivatives | PFIZER LIMITED | 2006-11-23 | — | — | US | disclosed |
| EP-1492789-B1 | TROPANE DERIVATIVES AS CCR5 MODULATORS | PFIZER LTD (GB) | 2006-06-07 | — | — | EP | disclosed |
| EP-1618874-A2 | PREVENTION OF HIV-1 INFECTION BY INHIBITION OF RHO-MEDIATED REORGANISATION AND/OR CONTENT ALTERATION OF CELL MEMBRANE RAFT DOMAINS | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2006-01-25 | — | — | EP | disclosed |
| US-20050131011-A1 | Chemical compounds | PFIZER, INC. | 2005-06-16 | — | — | US | disclosed |
| US-20050107424-A1 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. | 2005-05-19 | — | — | US | disclosed |
| US-6855724-B2 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040014742-A1 | Antiinflammatory agents; viricides | PFIZER INC. | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014742-A1 | Antiinflammatory agents; viricides | CCR5, CXCR1, CCR1 | KCNH2 2928/4885CCR5 1/4885 |
| US-20160355528-A1 | INHIBITORS OF HIV REPLICATION | RTF2, POLRMT, MAVS | KCNH2 4630/4885CCR5 139/4885 |
| US-20060264448-A1 | Purine derivatives | TLR9, TLR7, TLR1 | KCNH2 3022/4885CCR5 92/4885 |
| US-20050107424-A1 | Tropane derivatives useful in therapy | CCR5, CXCR4, CX3CR1 | KCNH2 3530/4885CCR5 1/4885 |
| US-20150336965-A1 | NOVEL ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | KCNH2 4125/4885CCR5 25/4885 |
| US-20140315927-A1 | Inhibitors of HIV Replication | RTF2, POLRMT, MAVS | KCNH2 4630/4885CCR5 139/4885 |
| US-20050131011-A1 | Chemical compounds | CCR5, CCR2, CX3CR1 | KCNH2 3565/4885CCR5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.