Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | HRH1 | P35367 | 3/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.73 |
| ▸ | DRD2 | P14416 | 3/20 | 0.73 |
| ▸ | HTR2A | P28223 | 2/20 | 0.73 |
| ▸ | HTR2B | P41595 | 2/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.73 |
| ▸ | HTR1A | P08908 | 2/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.73 |
| ▸ | DRD1 | P21728 | 2/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | MLNR | O43193 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | EGFR | P00533 | 1/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.73 |
| ▸ | FYN | P06241 | 1/20 | 0.73 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.73 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carebastine SCHEMBL18538 | 0.92 | LMNA (0.85) | DRD3LMNAHRH1KCNH2DRD2 | |
| Carebastine SCHEMBL26674085 | 0.91 | HTR2A (0.71) | DRD3LMNAHRH1KCNH2DRD2 | |
| Carebastine SCHEMBL26674069 | 0.88 | LMNA (0.78) | DRD3LMNAHRH1KCNH2DRD2 | |
| SCHEMBL12142398 | 0.87 | ADRA1A (0.79) | DRD3LMNAHRH1KCNH2DRD2 | |
| SCHEMBL12021980 | 0.87 | LMNA (0.62) | DRD3LMNAHRH1KCNH2DRD2 | |
| SCHEMBL8814073 | 0.84 | NPC1 (0.78) | DRD3LMNAHRH1KCNH2DRD2 | |
| Ebastine SCHEMBL18467 | 0.84 | ADRA1D (1.00) | DRD3LMNAHRH1KCNH2DRD2 | |
| SCHEMBL26674078 | 0.84 | DRD2 (0.69) | DRD3LMNAHRH1KCNH2DRD2 | |
| SCHEMBL6101514 | 0.84 | ADRA1D (0.81) | DRD3LMNAHRH1KCNH2DRD2 | |
| Carebastine SCHEMBL26674051 | 0.84 | ADRA1D (0.81) | DRD3LMNAHRH1KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476445-B2 | Process for production of piperidine derivatives | ALBANY MOLECULAR RESEARCH, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| US-20110295014-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-8022220-B2 | Process for production of piperidine derivatives | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20100137605-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-7691615-B2 | Process for the production of piperidine derivatives with microorganisms | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-7678915-B2 | Process for production of piperidine derivatives | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-20100010227-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-7560561-B2 | Process for production of piperidine derivatives | ALBANY MOLECULAR RESEARCH, INC. (US) | 2009-07-14 | — | — | US | disclosed |
| US-7232908-B2 | Process for the production of piperidine derivatives with microorganisms | AMR TECHNOLOGY, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-20070134774-A1 | PROCESS FOR THE PRODUCTION OF PIPERIDINE DERIVATIVES WITH MICROORGANISMS | AMR TECHNOLOGY, INC. (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070010677-A1 | Process for production of piperidine derivatives | AMR TECHNOLOGY, INC. (US) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110295014-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | OR10J3, NR1H2, NR1H3 | DRD3 448/4885LMNA 4284/4885HRH1 313/4885 |
| US-20100137605-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | HPD, PTMA, HAAO | DRD3 687/4885LMNA 2264/4885HRH1 727/4885 |
| US-20100010227-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | DDC, HPD, ALDH7A1 | DRD3 933/4885LMNA 2378/4885HRH1 882/4885 |
| US-20070010677-A1 | Process for production of piperidine derivatives | NR4A1, NR5A2, NR4A2 | DRD3 51/4885LMNA 4425/4885HRH1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.