SCHEMBL120277

SCHEMBL120277

CC(=O)c1ccc(F)cc1Br

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
F2R P25116 2/20 0.48
CES2 O00748 3/20 0.47
CES1 P23141 3/20 0.47
PKM P14618 2/20 0.43
MAOB P27338 4/20 0.41
MAOA P21397 2/20 0.41
ALDH1A1 P00352 1/20 0.39
KMT2A Q03164 1/20 0.39
MAPT P10636 2/20 0.38
KEAP1 Q14145 1/20 0.38
DGAT1 O75907 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30480694 1.00 F2R (0.48) F2RCES2CES1PKMMAOB
SCHEMBL7363929 0.88 F2R (0.47) F2RCES2CES1PKMMAOB
SCHEMBL29847023 0.83 F2R (0.48) F2RCES2CES1PKMMAOB
SCHEMBL485712 0.83 F2R (0.48) F2RCES2CES1PKMMAOB
SCHEMBL25270267 0.83 CES2 (0.50) F2RCES2CES1PKMALDH1A1
SCHEMBL111637 0.81 KEAP1 (0.53) F2RCES2CES1PKMALDH1A1
SCHEMBL4638742 0.79 DGAT1 (0.55) F2RCES2CES1PKMALDH1A1
SCHEMBL3711371 0.79 F2R (0.38) F2RCES2CES1PKMMAPT
SCHEMBL108131 0.79 CES2 (0.47) F2RCES2CES1PKMMAOB
SCHEMBL7981585 0.79 F2R (0.51) F2RCES2CES1PKMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 378 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117924196-A Novel IDH1 mutant inhibitor and application thereof 陕西中医药大学 2024-04-26 CN claimed
CN-116003260-B Method for preparing 1-naphthylamine compound from urea derivative and prediction model thereof 广州国家实验室 2023-07-18 CN claimed
CN-114950159-B Preparation method of aromatic polymer separation membrane based on super acid catalysis 南京工业大学 2023-06-06 CN claimed
CN-116003260-A Method for preparing 1-naphthylamine compound from urea derivative and prediction model thereof 广州国家实验室 2023-04-25 CN claimed
CN-113880786-A Synthesis method and antioxidant application of camphene aldehyde thiazole hydrazone derivative 江西农业大学 2022-01-04 CN claimed
CN-110092724-B Preparation method of N, N-dimethyl-1-naphthylamine compound 湖南大学 2021-08-31 CN claimed
EP-4735449-A1 TETRACYCLIC COMPOUNDS CONTAINING A FUSED INDOLE FOR TREATING APOL1-MEDIATED CHRONIC KIDNEY DISEASE OmniAB, Inc. (US) 2026-05-06 EP disclosed
EP-4698530-A1 NK3 MODULATORS AND USES THEREOF Kallyope, Inc. (US) 2026-02-25 EP disclosed
US-12459942-B2 Inhibiting (α-v)(β-6) integrin MORPHIC THERAPEUTIC, INC. (US) 2025-11-04 US disclosed
US-12404274-B2 Macrocycles as factor xia inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2025-09-02 US disclosed
US-20250263410-A1 NK3 MODULATORS AND USES THEREOF KALLYOPE, INC. 2025-08-21 US disclosed
WO-2025096751-A1 MACROCYCLIC INHIBITORS OF ATP CITRATE LYASE ESPERION THERAPEUTICS, INC. (US) 2025-05-08 WO disclosed
US-12281114-B2 NK3 modulators and uses thereof KALLYOPE, INC. (US) 2025-04-22 US disclosed
EP-0551632-B1 Process for the preparation of halogenoanthranilic acid RIEDEL DE HAEN AG (DE) 1996-06-26 EP disclosed
WO-1996003388-A1 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-02-08 WO disclosed
WO-1995021817-A1 SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1995-08-17 WO disclosed
WO-1995011883-A1 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1995-05-04 WO disclosed
US-5310746-A Insecticides, miticides, nematocides ROUSSEL UCLAF (FR) 1994-05-10 US disclosed
WO-1993024463-A1 SUBSTITUTED PYRAZOLINES AND THEIR USE AS PEST-CONTROL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1993-12-09 WO disclosed
EP-0551632-A2 Process for the preparation of halogenoanthranilic acid RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1993-07-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250263410-A1 NK3 MODULATORS AND USES THEREOF TAC3, TACR3, TACR2 F2R 656/4885CES2 4101/4885CES1 4144/4885
US-12459942-B2 Inhibiting (α-v)(β-6) integrin ITGB6, ITGA6, ITGAV F2R 576/4885CES2 3003/4885CES1 1757/4885
US-12404274-B2 Macrocycles as factor xia inhibitors TFPI, TFPI2, F11 F2R 21/4885CES2 4485/4885CES1 2137/4885
US-12281114-B2 NK3 modulators and uses thereof TAC3, TACR3, TACR2 F2R 656/4885CES2 4101/4885CES1 4144/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.