Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12124483 | 1.00 | GAA (0.60) | GAAMAPTATMMEN1KMT2A | |
| SCHEMBL12124406 | 0.84 | HTR1A (0.82) | GAAMAPTATMMEN1KMT2A | |
| SCHEMBL12124457 | 0.82 | SLC6A2 (0.75) | SLC6A2HTR2ASLC6A4SLC6A3 | |
| SCHEMBL12124485 | 0.82 | SLC6A2 (0.75) | SLC6A2HTR2ASLC6A4SLC6A3 | |
| SCHEMBL12124489 | 0.74 | CBX7 (0.55) | — | |
| SCHEMBL12124544 | 0.74 | DRD2 (0.76) | HTR1AHTR7 | |
| SCHEMBL12124706 | 0.73 | HTR1A (1.00) | HTR1AHTR7 | |
| SCHEMBL12124597 | 0.72 | HTR1A (0.61) | MEN1KMT2AHTR1AHTR7 | |
| SCHEMBL12124704 | 0.72 | HTR1A (0.82) | HTR1AHTR7 | |
| SCHEMBL12124530 | 0.72 | HTR1A (0.82) | HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102204-B1 | HIGHLY SELECTIVE SIGMA 1 RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHOPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | THE UNIV OF MISSISSIPPI (US) | 2021-05-05 | — | — | EP | disclosed |
| US-9724435-B2 | Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-08-08 | — | — | US | disclosed |
| US-9724435-B2 | Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-08-08 | — | — | US | disclosed |
| US-9604926-B2 | Highly selective sigma receptor radioligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-03-28 | — | — | US | disclosed |
| US-9604926-B2 | Highly selective sigma receptor radioligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-03-28 | — | — | US | disclosed |
| US-20140328755-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2014-11-06 | — | — | US | disclosed |
| US-20140328755-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2014-11-06 | — | — | US | disclosed |
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIV MISSISSIPPI (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIV MISSISSIPPI (US) | 2014-10-23 | — | — | US | disclosed |
| US-8809381-B2 | Highly selective sigma receptor ligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809381-B2 | Highly selective sigma receptor ligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2014-08-19 | — | — | US | disclosed |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | L'UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2011-08-11 | — | — | US | disclosed |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | L'UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2011-08-11 | — | — | US | disclosed |
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIVERSITY OF MISSISSIPPI (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIVERSITY OF MISSISSIPPI (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRL1, CNR1 | GAA 4551/4885MAPT 4660/4885ATM 3090/4885 |
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRD1, OPRM1 | GAA 4619/4885MAPT 4558/4885ATM 3169/4885 |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRD1, OPRM1 | GAA 4619/4885MAPT 4558/4885ATM 3169/4885 |
| US-20140328755-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | SIGMAR1, OPRL1, OPRK1 | GAA 3116/4885MAPT 1629/4885ATM 3900/4885 |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | SIGMAR1, MSR1, TMEM97 | GAA 4357/4885MAPT 4746/4885ATM 2637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.