Aristeromycin

Aristeromycin

SCHEMBL12157242

Nc1ncnc2c1ncn2[C@@H]1C[C@H](CO)[C@H](O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AHCY P23526 16/20 1.00
ADORA2B P29275 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aristeromycin SCHEMBL10353292 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL12280589 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL10353291 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL14515457 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL29695815 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL12173988 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL7534801 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL9820408 1.00 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL692209 1.00 AHCY (1.00) AHCYADORA2B
SCHEMBL15297972 0.99 AHCY (0.97) AHCYADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160145581-A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS HONG GUAN, LTD. (CN) 2016-05-26 US disclosed
US-20150266918-A1 Bridged-Cyclo-ProTides as Prodrugs of Therapeutic Nucleosides and Nucleotides ZHONG MINGHONG (US) 2015-09-24 US disclosed
US-20110269707-A1 Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation PHARMASSET, INC. 2011-11-03 US disclosed
US-7989430-B2 Antibacterial agents REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2011-08-02 US disclosed
US-20080293666-A1 Antibacterial Agents REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2008-11-27 US disclosed
US-7220870-B2 Hydrolytic kinetic resolution of cyclic substrates PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2007-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160145581-A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS AHCY, GSKIP, AHCYL1 AHCY 1/4885ADORA2B 1029/4885
US-20110269707-A1 Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation PNP, ALPP, XDH AHCY 4122/4885ADORA2B 388/4885
US-20150266918-A1 Bridged-Cyclo-ProTides as Prodrugs of Therapeutic Nucleosides and Nucleotides TYMP, ENPP3, PNP AHCY 3087/4885ADORA2B 147/4885
US-20080293666-A1 Antibacterial Agents MRPL21, ABCB7, MSR1 AHCY 3828/4885ADORA2B 955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.