Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23486383 | 0.81 | ALDH1A1 (0.47) | TSHRALDH1A1CYP1A2CYP2C9HSD17B10 | |
| SCHEMBL6969052 | 0.76 | TSHR (0.50) | TSHRALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL23486285 | 0.73 | ALDH1A1 (0.50) | TSHRALDH1A1CYP1A2CYP2C9HSD17B10 | |
| SCHEMBL23453753 | 0.72 | SRD5A2 (0.54) | ALDH1A1CYP1A2CYP2C9HSD17B10 | |
| Hydrogen Peroxide SCHEMBL28758135 | 0.70 | TSHR (0.94) | TSHRALDH1A1CYP1A2KMT2AKDM4E | |
| Terephthalic Acid SCHEMBL11039705 | 0.69 | NR4A2 (0.69) | TSHRALDH1A1KMT2AMEN1NR4A1 | |
| SCHEMBL18869086 | 0.69 | TDP1 (0.50) | TSHRALDH1A1KMT2AILKKDM4E | |
| SCHEMBL22005508 | 0.69 | ILK (0.51) | TSHRALDH1A1KMT2AMEN1ILK | |
| Acetic Acid SCHEMBL28710458 | 0.68 | TSHR (0.71) | TSHRALDH1A1KMT2AMAPK1L3MBTL1 | |
| Acetic Acid SCHEMBL4466285 | 0.68 | TSHR (0.71) | TSHRALDH1A1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120232107-A1 | NON-PEPTIDE ANTAGONISTS OF GASTRIN RELEASING PEPTIDE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH | 2012-09-13 | — | — | US | disclosed |
| US-20120232107-A1 | NON-PEPTIDE ANTAGONISTS OF GASTRIN RELEASING PEPTIDE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH | 2012-09-13 | — | — | US | disclosed |
| US-20080249115-A1 | small molecule, non-peptide, modulators (e.g., antagonists or agonists) of peptide hormones; treating low blood pressure or an eating disorder | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS (US) | 2008-10-09 | — | — | US | disclosed |
| US-20080249115-A1 | small molecule, non-peptide, modulators (e.g., antagonists or agonists) of peptide hormones; treating low blood pressure or an eating disorder | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232107-A1 | NON-PEPTIDE ANTAGONISTS OF GASTRIN RELEASING PEPTIDE | GRPR, GIPR, CCKBR | TSHR 189/4885ALDH1A1 4802/4885CYP1A2 4866/4885 |
| US-20080249115-A1 | small molecule, non-peptide, modulators (e.g., antagonists or agonists) of peptide hormones; treating low blood pressure or an eating disorder | GIPR, GRPR, CRH | TSHR 301/4885ALDH1A1 4862/4885CYP1A2 4811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.