Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945044 | 0.84 | RAB9A (0.52) | CASP3HPGDRAB9AMAPTLMNA | |
| SCHEMBL31217454 | 0.82 | MAPT (0.51) | CASP3HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12230834 | 0.76 | G6PD (0.74) | CASP3HPGDG6PD | |
| SCHEMBL11748157 | 0.75 | MTNR1B (0.68) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL7945993 | 0.74 | KMT2A (0.49) | CASP3RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL11671917 | 0.73 | ALDH1A1 (0.55) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL11645434 | 0.72 | XIAP (0.58) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL15195144 | 0.71 | S1PR1 (0.44) | CASP3HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12863549 | 0.70 | MITF (0.58) | L3MBTL1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7940591 | 0.68 | GAA (0.46) | CASP3L3MBTL1SMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9428472-B2 | Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives | GEORGETOWN UNIVERSITY (US) | 2016-08-30 | — | — | US | disclosed |
| US-9040715-B2 | 1,2-benzisothiazolinone and isoindolinone derivatives | GEORGETOWN UNIVERSITY (US) | 2015-05-26 | — | — | US | disclosed |
| EP-2344479-B1 | 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES | UNIV GEORGETOWN (US) | 2015-04-08 | — | — | EP | disclosed |
| US-20140296310-A1 | METHODS OF TREATING BACTERIAL INFECTIONS WITH 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES | GEORGETOWN UNIVERSITY (US) | 2014-10-02 | — | — | US | disclosed |
| WO-2013025897-A1 | METHODS OF TREATING BACTERIAL INFECTIONS WITH 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES | GEORGETOWN UNIVERSITY (US) | 2013-02-21 | — | — | WO | disclosed |
| US-20110251193-A1 | 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES | WICHITA STATE UNIVERSITY (US) | 2011-10-13 | — | — | US | disclosed |
| WO-2010039545-A2 | 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES | GEORGETOWN UNIVERSITY (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296310-A1 | METHODS OF TREATING BACTERIAL INFECTIONS WITH 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES | VIP, VIL1, BAK1 | CASP3 75/4885L3MBTL1 922/4885HPGD 231/4885 |
| US-20110251193-A1 | 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES | HAVCR2, ERG28, ZC3HAV1 | CASP3 957/4885L3MBTL1 2756/4885HPGD 1778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.