Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.70 |
| ▸ | RELA | Q04206 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 11/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.64 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585750 | 0.89 | MEN1 (0.88) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL2753872 | 0.88 | LMNA (0.77) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL28575125 | 0.84 | MAPT (0.72) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL10072694 | 0.84 | ALOX5 (0.74) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL1819906 | 0.84 | RAB9A (0.78) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL233522 | 0.83 | SCD (0.78) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL27885076 | 0.83 | NFKB1 (1.00) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL20379817 | 0.82 | CSNK2A1 (0.75) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL12316832 | 0.82 | MEN1 (0.79) | MEN1KMT2ANFKB1NFKB2RELA | |
| SCHEMBL17320209 | 0.82 | ALOX5 (0.85) | MEN1KMT2AMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20160171150-A1 | Chemical Modulators of Pro-Apoptotic BAX and BCL-2 Polypeptides | DANA-FARBER CANCER INSTITUTE, INC. | 2016-06-16 | — | — | US | disclosed |
| US-20160171150-A1 | Chemical Modulators of Pro-Apoptotic BAX and BCL-2 Polypeptides | DANA-FARBER CANCER INSTITUTE, INC. | 2016-06-16 | — | — | US | disclosed |
| US-20110218155-A1 | CHEMICAL MODULATORS OF PRO-APOPTOTIC BAX AND BCL-2 POLYPEPTIDES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20110218155-A1 | CHEMICAL MODULATORS OF PRO-APOPTOTIC BAX AND BCL-2 POLYPEPTIDES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | MEN1 3416/4885KMT2A 3471/4885NFKB1 487/4885 |
| US-20110218155-A1 | CHEMICAL MODULATORS OF PRO-APOPTOTIC BAX AND BCL-2 POLYPEPTIDES | BAX, BCL2, BCL2L1 | MEN1 3300/4885KMT2A 3136/4885NFKB1 705/4885 |
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | MEN1 2434/4885KMT2A 2501/4885NFKB1 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.