Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 9/20 | 0.49 |
| ▸ | MERTK | Q12866 | 9/20 | 0.49 |
| ▸ | FLT3 | P36888 | 7/20 | 0.49 |
| ▸ | GAS6 | Q14393 | 6/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 4/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12825848 | 0.93 | IGF1R (0.49) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8234173 | 0.77 | FLT3 (0.49) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18293823 | 0.74 | PRKCQ (0.48) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16842132 | 0.73 | PRKCQ (0.57) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14869658 | 0.70 | HTR6 (0.62) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14391028 | 0.70 | TYRO3 (0.54) | IGF1RTYRO3MERTKFLT3GAS6 | |
| SCHEMBL15256329 | 0.70 | IGF1R (0.54) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4376091 | 0.69 | ADORA1 (0.49) | IGF1RFLT3ADORA3ADORA2AADORA2B | |
| SCHEMBL6644966 | 0.68 | ALDH1A1 (0.52) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1801288 | 0.68 | ADORA3 (0.54) | CHRM3PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230480-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | COLE ANDREW G | 2011-09-22 | — | — | US | disclosed |
| US-20110230480-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | COLE ANDREW G | 2011-09-22 | — | — | US | disclosed |
| US-7951803-B2 | 8-heteroarylpurine MNK2 inhibitors for treating metabolic disorders | PHARMACOPEIA, LLC (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951803-B2 | 8-heteroarylpurine MNK2 inhibitors for treating metabolic disorders | PHARMACOPEIA, LLC (US) | 2011-05-31 | — | — | US | disclosed |
| US-20080032971-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2008-02-07 | — | — | US | disclosed |
| US-20080032971-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2008-02-07 | — | — | US | disclosed |
| WO-2007104053-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230480-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PCK2, UCK2, PANK2 | CHRM3 4338/4885PDE4A 2846/4885PDE4B 2447/4885 |
| US-20080032971-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PCK2, UCK2, PANK2 | CHRM3 4338/4885PDE4A 2846/4885PDE4B 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.