Cinnamic Acid

Cinnamic Acid

SCHEMBL123137

O=C([O-])C=Cc1ccccc1.[Na+]

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Cinnamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.64
HDAC3 O15379 2/20 0.64
HDAC4 P56524 2/20 0.64
HDAC1 Q13547 2/20 0.64
HDAC2 Q92769 2/20 0.64
HDAC8 Q9BY41 2/20 0.64
HDAC6 Q9UBN7 2/20 0.64
PLIN1 O60240 2/20 0.64
LMNA P02545 2/20 0.64
RECQL P46063 2/20 0.64
PLIN5 Q00G26 2/20 0.64
ABHD5 Q8WTS1 2/20 0.64
ALDH1A1 P00352 2/20 0.64
F3 P13726 2/20 0.64
TNKS O95271 1/20 0.64
HCAR2 Q8TDS4 1/20 0.64
HDAC7 Q8WUI4 1/20 0.64
HDAC10 Q969S8 1/20 0.64
HDAC11 Q96DB2 1/20 0.64
TNKS2 Q9H2K2 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cinnamic Acid SCHEMBL28196652 1.00 MAPT (0.64) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL123136 1.00 MAPT (0.64) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL9514555 0.98 MAPT (0.61) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL10899356 0.98 MAPT (0.67) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL10899352 0.98 MAPT (0.67) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL122245 0.98 MAPT (0.67) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL122244 0.98 MAPT (0.67) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL2816034 0.95 MAPT (0.64) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL10899371 0.95 MAPT (0.64) MAPTHDAC3HDAC4HDAC1HDAC2
Cinnamic Acid SCHEMBL2455274 0.95 MAPT (0.64) MAPTHDAC3HDAC4HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1041 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250250172-A1 HARD CARBON MATERIAL, NEGATIVE ELECTRODE PLATE, SECONDARY BATTERY, AND ELECTRIC APPARATUS NINGDE AMPEREX TECHNOLOGY LIMITED (CN) 2025-08-07 US claimed
CN-120117619-A Method for adjusting acid center of molecular sieve at fixed point 中国石油化工股份有限公司 2025-06-10 CN claimed
CN-119736070-A Composite phase change material adopting double-network encapsulation and preparation method thereof 华东理工大学 2025-04-01 CN claimed
CN-119744075-A Composite material, preparation method thereof, light-emitting device and electronic equipment TCL科技集团股份有限公司 2025-04-01 CN claimed
CN-119388614-A Preparation device and preparation process of multi-metal master batch 青岛鑫盈鑫包装材料有限公司 2025-02-07 CN claimed
US-12178942-B2 Method for manufacturing stent for drug release, including flexible nanostructured film connected in three dimensions, and stent for drug release prepared thereby KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2024-12-31 US claimed
CN-119083242-A PHA laminated paper 北京微构工场生物技术有限公司 2024-12-06 CN claimed
CN-114805657-B Ion exchange polymer microsphere and synthesis method thereof 中国科学院大连化学物理研究所 2024-11-12 CN claimed
CN-118854459-A High nickel-base single crystal positive electrode precursor, positive electrode material, preparation method of positive electrode material, positive electrode and battery 广东邦普循环科技有限公司 2024-10-29 CN claimed
CN-117866404-B Preparation method of halogen-free flame-retardant PC/ABS/PET material 东莞市国亨塑胶科技有限公司 2024-07-26 CN claimed
US-5574816-A NUCLEATION AGENT ALCATEL NA CABLE SYTEMS, INC. (US) 1996-11-12 US claimed
US-5565022-A Fast drying, bleed-free ink-jet ink compositions HEWLETT-PACKARD COMPANY (US) 1996-10-15 US claimed
WO-1996023239-A2 POLYPROPYLENE-POLYETHYLENE COPOLYMER BUFFER TUBES FOR OPTICAL FIBER CABLES AND METHOD FOR MAKING THE SAME ALCATEL NA CABLE SYSTEMS, INC. (US) 1996-08-01 WO claimed
US-5531816-A Bleed-alleviated, waterfast, pigment-based ink-jet ink compositions HEWLETT-PACKARD COMPANY (US) 1996-07-02 US claimed
EP-0492803-A1 Stabilized halogen containing polymer compositions ELF ATOCHEM NORTH AMERICA, INC. (US) 1992-07-01 EP claimed
US-4687761-A FERULIC ACID, ANETHOLE, GINSENOSIDE, AND SODIUM CINNAMATE L. Y. HOLDING COMPANY, LTD. (BS) 1987-08-18 US claimed
US-RE32459-E CINNAMIC ACID THINNER AKZO N.V. (NL) 1987-07-14 US claimed
EP-0201784-A2 Pharmaceutical composition decreasing side effects of anticancer chemotherapy and increasing the immune function Liu, Yaguang (US) 1986-11-20 EP claimed
EP-0010918-B1 ANTIFREEZE AGENTS Smiths Industries Public Limited Company (GB) 1983-04-13 EP claimed
EP-0010918-A1 Antifreeze agents Smiths Industries Public Limited Company (GB) 1980-05-14 EP claimed