SCHEMBL1232173

SCHEMBL1232173

COC(=O)c1ccc(C)c(I)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.53
CA1 P00915 3/20 0.53
CA2 P00918 3/20 0.53
CA12 O43570 2/20 0.53
CA7 P43166 2/20 0.53
CA9 Q16790 2/20 0.53
CA14 Q9ULX7 2/20 0.53
XDH P47989 1/20 0.53
ALDH1A1 P00352 5/20 0.51
NOTUM Q6P988 1/20 0.50
MAPT P10636 4/20 0.49
KDM4E B2RXH2 2/20 0.49
HPGD P15428 2/20 0.49
HSD17B10 Q99714 2/20 0.49
GAA P10253 2/20 0.49
GLA P06280 1/20 0.49
CASP1 P29466 1/20 0.49
CASP7 P55210 1/20 0.49
ATM Q13315 1/20 0.49
CYP2C9 P11712 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30010685 1.00 TDP1 (0.53) TDP1CA1CA2CA12CA7
SCHEMBL1459771 0.85 TDP1 (0.53) TDP1CA1CA2CA12CA7
SCHEMBL550572 0.84 CA1 (0.57) TDP1CA1CA2CA12CA7
SCHEMBL204112 0.82 CA1 (0.55) TDP1CA1CA2CA12CA7
SCHEMBL17656285 0.82 HCRTR1 (0.48) TDP1CA1CA2CA12CA7
SCHEMBL35783 0.82 MAPT (0.63) TDP1CA1CA2CA12CA7
SCHEMBL30029511 0.82 MAPT (0.63) TDP1CA1CA2CA12CA7
SCHEMBL30410030 0.81 CA12 (0.59) CA1CA2CA12CA7CA9
SCHEMBL2228061 0.81 CA12 (0.59) CA1CA2CA12CA7CA9
SCHEMBL490266 0.81 KDM4E (0.62) TDP1CA1CA2CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 296 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119462376-A Synthesis process of panatinib key intermediate 湖北广济医药科技有限公司 2025-02-18 CN claimed
CN-116284074-A Synthesis process of 5-carboxylic acid-2-methylphenylboronic acid 上海泰坦科技股份有限公司 2023-06-23 CN claimed
CN-103664951-B A kind of preparation method treating chronic myelocytic leukemia medicine 南京圣和药业股份有限公司 2016-10-05 CN claimed
CN-103664951-A Preparation method of drug for treating chronic granulocytic leukemia NANJING SANHOME PHARMACEUTICAL CO LTD 2014-03-26 CN claimed
CN-120842220-B Aryl amide compound and application thereof 暨南大学 2026-05-19 CN disclosed
EP-4739682-A1 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS Janssen Pharmaceutica NV (BE) 2026-05-13 EP disclosed
US-12509424-B2 Compound and composition as PDGF receptor kinase inhibitor NIPPON SHINYAKU CO., LTD. (JP) 2025-12-30 US disclosed
US-12440494-B2 Compounds useful for inhibiting RAF dimers ALBERT EINSTEIN COLLEGE OF MEDICINE (US) 2025-10-14 US disclosed
US-20250304535-A1 KAT6 Inhibitors BEIGENE SWITZERLAND GMBH (CH) 2025-10-02 US disclosed
WO-2025201504-A1 KAT6 INHIBITORS BEIGENE (SUZHOU) CO., LTD. (CN) 2025-10-02 WO disclosed
US-12312348-B2 RET inhibitors, pharmaceutical compositions and uses thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2025-05-27 US disclosed
EP-4516777-A2 COMPOUND AND COMPOSITION AS PDGF RECEPTOR KINASE INHIBITOR Nippon Shinyaku Co., Ltd. (JP) 2025-03-05 EP disclosed
US-20060199845-A1 Thiophene compounds for inflammation and immune-related uses SYNTA PHARMACEUTICALS CORP. (US) 2006-09-07 US disclosed
WO-2006083477-A2 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2006-08-10 WO disclosed
WO-2006083477-A2 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2006-08-10 WO disclosed
US-20060173006-A1 Compounds for inflammation and immune-related uses SYNTA PHARMACEUTICALS CORP. (US) 2006-08-03 US disclosed
WO-2006081389-A1 THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2006-08-03 WO disclosed
US-20060166990-A1 Novel aminobenzophenone compounds LEO PHARMA A/S (DK) 2006-07-27 US disclosed
EP-1658263-A1 NOVEL AMINOBENZOPHENONE COMPOUNDS Leo Pharma A/S (DK) 2006-05-24 EP disclosed
WO-2005009940-A1 NOVEL AMINOBENZOPHENONE COMPOUNDS LEO PHARMA A/S (DK) 2005-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304535-A1 KAT6 Inhibitors KAT6A, KAT6B, KAT2A TDP1 882/4885CA1 1153/4885CA2 3028/4885
US-20060166990-A1 Novel aminobenzophenone compounds NFKBIA, UACA, ALDH7A1 TDP1 2935/4885CA1 4843/4885CA2 3933/4885
US-12509424-B2 Compound and composition as PDGF receptor kinase inhibitor PDGFRA, PDGFRB, PDGFA TDP1 2525/4885CA1 3118/4885CA2 339/4885
US-12440494-B2 Compounds useful for inhibiting RAF dimers BRAF, RAF1, NRAS TDP1 1623/4885CA1 1112/4885CA2 1425/4885
US-12312348-B2 RET inhibitors, pharmaceutical compositions and uses thereof RET, SLC10A2, REL TDP1 1419/4885CA1 1014/4885CA2 449/4885
US-20060199845-A1 Thiophene compounds for inflammation and immune-related uses CXCR2, TPMT, CXCR1 TDP1 1817/4885CA1 1366/4885CA2 407/4885
US-20060173006-A1 Compounds for inflammation and immune-related uses CXCL8, CCR8, CXCR2 TDP1 3644/4885CA1 719/4885CA2 197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.