Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14370514 | 1.00 | ACACB (0.58) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL5052802 | 0.87 | ADRA1D (0.53) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL5052805 | 0.87 | ADRA1D (0.53) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL5059309 | 0.87 | ADRA1D (0.56) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL14300657 | 0.87 | ADRA1D (0.53) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL5059304 | 0.87 | ADRA1D (0.56) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL1412301 | 0.86 | ADRA1D (0.59) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL1412297 | 0.86 | ADRA1D (0.59) | ACACBADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL13067728 | 0.84 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL4356427 | 0.83 | ADRA1D (0.45) | ACACBADRA1DADRA1AADRA1BADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017803-B2 | Process for the preparation of tamsulosin and intermediates thereof | HOVIONE INTER LTD. (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1734036-B1 | Process for preparation of tamsulosin and its derivatives | WELL BEING BIOCHEMICAL CORP (TW) | 2011-08-31 | — | — | EP | disclosed |
| EP-1996544-B1 | A METHOD OF PREPARATION OF (R)-(-)-5(2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE | ZENTIVA KS (CZ) | 2010-11-10 | — | — | EP | disclosed |
| US-7638649-B2 | Method of preparation of (R)-(−)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide | ZENTIVA, K.S. (CZ) | 2009-12-29 | — | — | US | disclosed |
| US-20090234154-A1 | Process for the preparation of tamsulosin and intermediates thereof | HOVIONE INTER LTD. | 2009-09-17 | — | — | US | disclosed |
| US-20080319225-A1 | Method of Preparation of (R)-(-)-5(2-Aminopropyl)-2-Methoxybenzenesulfonamide | ZENTIVA, A.S. (CZ) | 2008-12-25 | — | — | US | disclosed |
| US-7282606-B2 | Process for preparation of tamsulosin and its aralkylamine derivatives | WELL-BEING BIOCHEMICAL CORP. (TW) | 2007-10-16 | — | — | US | disclosed |
| US-20070015939-A1 | Process for preparation of tamsulosin and its aralkylamine derivatives | WELL-BEING BIOCHEMICAL CORP (TW) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234154-A1 | Process for the preparation of tamsulosin and intermediates thereof | AVPR2, AVPR1B, TACR2 | ACACB 3833/4885ADRA1D 31/4885ADRA1A 57/4885 |
| US-20080319225-A1 | Method of Preparation of (R)-(-)-5(2-Aminopropyl)-2-Methoxybenzenesulfonamide | NPSR1, TPSAB1, TPSB2 | ACACB 4272/4885ADRA1D 22/4885ADRA1A 45/4885 |
| US-20070015939-A1 | Process for preparation of tamsulosin and its aralkylamine derivatives | ADRB1, ADRA2B, ADRA2A | ACACB 2883/4885ADRA1D 7/4885ADRA1A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.