Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | CA12 | O43570 | 2/20 | 0.69 |
| ▸ | CA9 | Q16790 | 2/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.64 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.64 |
| ▸ | ITGAV | P06756 | 1/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.64 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233002 | 1.00 | PKM (0.70) | PKMCA12CA9CA2ITGB3 | |
| SCHEMBL12425742 | 0.93 | PKM (0.70) | PKMCA12CA9CA2ITGB3 | |
| SCHEMBL5583041 | 0.91 | PTPN1 (0.64) | PKMCA12CA9CA2ITGB3 | |
| SCHEMBL5583040 | 0.91 | PTPN1 (0.64) | PKMCA12CA9CA2ITGB3 | |
| SCHEMBL27923704 | 0.89 | KMT2A (0.75) | PKMCA12CA9CA2PTPN1 | |
| SCHEMBL1233571 | 0.87 | HDAC2 (0.67) | CA12CA9CA2PTPN1NPC1 | |
| SCHEMBL1233568 | 0.87 | HDAC2 (0.67) | CA12CA9CA2PTPN1NPC1 | |
| SCHEMBL6965107 | 0.86 | GAA (0.67) | PKMCA12CA9CA2ITGB3 | |
| SCHEMBL6965101 | 0.86 | GAA (0.67) | PKMCA12CA9CA2ITGB3 | |
| SCHEMBL7948225 | 0.86 | MITF (0.64) | PKMPTPN1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105572-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2011-05-05 | — | — | US | disclosed |
| US-7880020-B2 | e.g trichlorostatin A; antiproliferative agent; for treating cancer and psoriasis | TOPOTARGET UK LIMITED (GB) | 2011-02-01 | — | — | US | disclosed |
| US-20100249197-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2010-09-30 | — | — | US | disclosed |
| US-7569724-B2 | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2009-08-04 | — | — | US | disclosed |
| EP-2083005-A1 | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| US-20070010695-A1 | Diphosphines, preparation and uses thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2007-01-11 | — | — | US | disclosed |
| EP-1598067-A1 | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2005-11-23 | — | — | EP | disclosed |
| WO-2005082819-A2 | METAL COMPLEXES FOR USE IN OLEFIN METATHESIS AND ATOM GROUP TRANSFER REACTIONS | UNIVERSITEIT GENT (BE) | 2005-09-09 | — | — | WO | disclosed |
| US-20040102649-A1 | Water soluble chiral diphoshpines | RHODIA CHIMIE (FR) | 2004-05-27 | — | — | US | disclosed |
| US-20040092598-A1 | Carbamic acid compounds comprising an amide linkage as hdac inhibitors | TOPOTARGET UK LIMITED (GB) | 2004-05-13 | — | — | US | disclosed |
| US-6380412-B1 | HYDROGENATION CATALYSTS | RHONE-POULENC CHIMIE (FR) | 2002-04-30 | — | — | US | disclosed |
| US-20020042540-A1 | New 6,6'-bis-(1-phosphanorbornadiene) diphosphines, their preparation and their uses | MATHEY FRANCOIS (FR) | 2002-04-11 | — | — | US | disclosed |
| WO-2002026696-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | PROLIFIX LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |
| US-6288279-B1 | THEIR PREPARATION PROCESS AND THEIR USE IN ASYMMETRICAL CATALYSIS. REARRANGING A DIPHOSPHOLE, REACTING THE DIPHOSPHOLE WITH AN ACETYLENIC COMPOUND TO FORM THE DIPHOSPHINE | RHODIA CHIMIE (FR) | 2001-09-11 | — | — | US | disclosed |
| US-6037493-A | Optically active diphosphines, preparation thereof according to a process for the resolution of the racemic mixture and use thereof | RHONE-POULENC CHIMIE (FR) | 2000-03-14 | — | — | US | disclosed |
| US-5783738-A | Optically active diphosphines, preparation thereof according to a process for the resolution of the racemic mixture and use thereof | RHONE-POULENC CHIMIE (FR) | 1998-07-21 | — | — | US | disclosed |
| EP-0322236-B1 | Catalytic process for preparing optically active threonine | TAKASAGO PERFUMERY CO LTD (JP) | 1994-05-04 | — | — | EP | disclosed |
| EP-0174057-B1 | RUTHENIUM-PHOSPHINE COMPLEX CATALYSTS | Takasago Perfumery Co., Ltd. (JP) | 1988-08-24 | — | — | EP | disclosed |
| US-4691037-A | CATALYSTS | TAKASAGO PERFUMERY CO., LTD. (JP) | 1987-09-01 | — | — | US | disclosed |
| EP-0174057-A2 | Ruthenium-phosphine complex catalysts | Takasago Perfumery Co., Ltd. (JP) | 1986-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092598-A1 | Carbamic acid compounds comprising an amide linkage as hdac inhibitors | HDAC1, HDAC11, HDAC3 | PKM 1756/4885CA12 1364/4885CA9 1221/4885 |
| US-20110105572-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | HDAC1, HDAC7, HDAC5 | PKM 1854/4885CA12 664/4885CA9 271/4885 |
| US-20040102649-A1 | Water soluble chiral diphoshpines | ADRA1B, ADRB1, ADRA1A | PKM 4073/4885CA12 3413/4885CA9 3167/4885 |
| US-20100249197-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | HDAC1, HDAC11, HDAC3 | PKM 1550/4885CA12 1456/4885CA9 1240/4885 |
| US-20020042540-A1 | New 6,6'-bis-(1-phosphanorbornadiene) diphosphines, their preparation and their uses | PHOSPHO1, DUS2, DCPS | PKM 2573/4885CA12 3664/4885CA9 3440/4885 |
| US-20070010695-A1 | Diphosphines, preparation and uses thereof | MPI, ITPA, DCPS | PKM 1910/4885CA12 3105/4885CA9 2383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.