Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10427470 | 0.83 | NPC1 (0.47) | HPGDSMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL12336612 | 0.82 | GAA (0.55) | SMN1; SMN2LMNAGAAALDH1A1MEN1 | |
| SCHEMBL2993849 | 0.80 | ALDH1A1 (0.53) | PTGS2HPGDSMN1; SMN2LMNAGAA | |
| SCHEMBL2989634 | 0.78 | ALDH1A1 (0.51) | PTGS2HPGDSMN1; SMN2LMNAGAA | |
| SCHEMBL2989640 | 0.78 | ALDH1A1 (0.51) | PTGS2HPGDSMN1; SMN2LMNAGAA | |
| SCHEMBL2989637 | 0.78 | ALDH1A1 (0.51) | PTGS2HPGDSMN1; SMN2LMNAGAA | |
| SCHEMBL5139150 | 0.78 | NPC1 (0.46) | HPGDSMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL400890 | 0.71 | RAB9A (0.77) | PTGS2SMN1; SMN2GAARAB9ANPC1 | |
| SCHEMBL425101 | 0.70 | PTGS2 (1.00) | PTGS2HPGDSMN1; SMN2GAARAB9A | |
| SCHEMBL8533642 | 0.69 | ALDH1A1 (0.50) | HPGDSMN1; SMN2LMNAGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119869-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE DISEASES | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 2011-09-29 | — | — | WO | disclosed |