SCHEMBL12341462

SCHEMBL12341462

COCCOCCOC(=O)NC1C(O)CC(OC(C)C)(C(=O)O)OC1C(O)C(O)CO

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ NANP Q8TBE9 3/20 0.47
▸ SIGLEC7 Q9Y286 4/20 0.38
▸ CD22 P20273 4/20 0.38
▸ MAG P20916 2/20 0.38
▸ SELL P14151 1/20 0.38
▸ SELP P16109 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13402335 0.93 NANP (0.43) NANPSIGLEC7CD22MAGSELL
SCHEMBL12730475 0.92 NANP (0.44) NANPCD22MAG
SCHEMBL12341443 0.92 NANP (0.44) NANPCD22MAG
SCHEMBL14454528 0.92 NANP (0.44) NANPCD22MAG
SCHEMBL14000588 0.88 NANP (0.45) NANPSIGLEC7CD22MAGSELL
SCHEMBL12341459 0.86 NANP (0.39) NANPCD22MAG
SCHEMBL5532089 0.83 NANP (0.35) NANPSIGLEC7CD22MAG
SCHEMBL15677307 0.83 NANP (0.51) NANPCD22MAG
SCHEMBL13402333 0.83 CD22 (0.38) NANPCD22
SCHEMBL14175641 0.83 NANP (0.40) NANPCD22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9029331-B2 Glycopegylated granulocyte colony stimulating factor NOVO NORDISK A/S (DK) 2015-05-12 — — US disclosed
US-8911967-B2 One pot desialylation and glycopegylation of therapeutic peptides NOVO NORDISK A/S (DK) 2014-12-16 — — US disclosed
US-8404809-B2 Glycopegylated factor IX NOVO NORDISK A/S (DK) 2013-03-26 — — US disclosed
US-8268967-B2 Glycopegylated interferon α NOVO NORDISK A/S (DK) 2012-09-18 — — US disclosed
US-7956032-B2 Glycopegylated granulocyte colony stimulating factor NOVO NORDISK A/S (DK) 2011-06-07 — — US disclosed
US-20100330645-A1 ONE POT DESIALYLATION AND GLYCOPEGYLATION OF THERAPEUTIC PEPTIDES NOVO NORDISK A/S (DK) 2010-12-30 — — US disclosed
US-7842661-B2 Glycopegylated erythropoietin formulations NOVO NORDISK A/S (DK) 2010-11-30 — — US disclosed
US-20100210507-A9 Glycopegylated erythropoietin NOVO NORDISK A/S (DK) 2010-08-19 — — US disclosed
US-20100113743-A1 GLYCOPEGYLATED FACTOR VII AND FACTOR VIIA NOVO NORDISK A/S (DK) 2010-05-06 — — US disclosed
US-20090292110-A1 Enzymatic modification of glycopeptides BIOGENERIX AG (DE) 2009-11-26 — — US disclosed
US-20090203579-A1 Glycopegylated Granulocyte Colony Stimulating Factor NOVO NORDISK A/S (DK) 2009-08-13 — — US disclosed
US-20090081188-A1 GLYCOPEGYLATED FACTOR IX NEOSE TECHNOLOGIES, INC. (US) 2009-03-26 — — US disclosed
US-20080305992-A1 Glycopegylated erythropoietin NEOSE TECHNOLOGIES, INC. (US) 2008-12-11 — — US disclosed
US-20080255026-A1 Glycopegylated Factor Ix GLYCOPEGYLATED FACTOR 1X 2008-10-16 — — US disclosed
US-20080176790-A1 Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) 89BIO, INC. 2008-07-24 — — US disclosed
US-20080146782-A1 GLYCEROL LINKED PEGYLATED SUGARS AND GLYCOPEPTIDES NEOSE TECHNOLOGIES, INC. (US) 2008-06-19 — — US disclosed
US-20070154992-A1 Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants NEOSE TECHNOLOGIES, INC. (US) 2007-07-05 — — US disclosed
US-20070105755-A1 One pot desialylation and glycopegylation of therapeutic peptides NEOSE TECHNOLOGIES, INC. (US) 2007-05-10 — — US disclosed
US-20070014759-A1 Glycopegylated granulocyte colony stimulating factor NEOSE TECHNOLOGIES, INC. (US) 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080176790-A1 Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) FGF2, FGF1, FGFR1 NANP 163/4885SIGLEC7 205/4885CD22 392/4885
US-20080146782-A1 GLYCEROL LINKED PEGYLATED SUGARS AND GLYCOPEPTIDES UGCG, B3GAT3, UGGT1 NANP 306/4885SIGLEC7 16/4885CD22 367/4885
US-20090081188-A1 GLYCOPEGYLATED FACTOR IX F9, F13A1, F13B NANP 160/4885SIGLEC7 43/4885CD22 382/4885
US-20100210507-A9 Glycopegylated erythropoietin EPOR, UGGT1, GNE NANP 864/4885SIGLEC7 71/4885CD22 290/4885
US-20090203579-A1 Glycopegylated Granulocyte Colony Stimulating Factor CSF3R, GMFG, GALNT1 NANP 701/4885SIGLEC7 6/4885CD22 203/4885
US-20080255026-A1 Glycopegylated Factor Ix F9, F13A1, F13B NANP 156/4885SIGLEC7 46/4885CD22 390/4885
US-20100113743-A1 GLYCOPEGYLATED FACTOR VII AND FACTOR VIIA F7, F13B, F13A1 NANP 431/4885SIGLEC7 23/4885CD22 1638/4885
US-20090292110-A1 Enzymatic modification of glycopeptides ENGASE, DNPEP, ENPEP NANP 41/4885SIGLEC7 53/4885CD22 321/4885
US-20070105755-A1 One pot desialylation and glycopegylation of therapeutic peptides UGGT1, PTMS, GALNT1 NANP 832/4885SIGLEC7 33/4885CD22 210/4885
US-20070014759-A1 Glycopegylated granulocyte colony stimulating factor CSF3R, GMFG, GALNT1 NANP 701/4885SIGLEC7 6/4885CD22 203/4885
US-20080305992-A1 Glycopegylated erythropoietin EPOR, UGGT1, GNE NANP 864/4885SIGLEC7 71/4885CD22 290/4885
US-20070154992-A1 Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants GHITM, PTMS, GHRHR NANP 386/4885SIGLEC7 853/4885CD22 2233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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