Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.97 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | GFER | P55789 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.97 |
| ▸ | HTR1A | P08908 | 6/20 | 0.97 |
| ▸ | TP53 | P04637 | 5/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.97 |
| ▸ | DRD1 | P21728 | 5/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promazine SCHEMBL29390978 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL140489 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL29392545 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL9052694 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL27429489 | 0.97 | CYP2D6 (0.97) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL27425063 | 0.97 | CYP2D6 (0.97) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL123419 | 0.95 | CYP2D6 (0.94) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL28239574 | 0.94 | CYP2D6 (0.91) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| SCHEMBL6865346 | 0.93 | CYP2D6 (0.90) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Fenethazine SCHEMBL662746 | 0.90 | KDM1A (0.96) | LMNAMAPTSMN1; SMN2PMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1501 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3444337-B1 | METHOD OF CLEANING | PROCTER & GAMBLE (US) | 2024-12-18 | — | — | EP | claimed |
| CN-118680906-B | Quick-dissolving-out calicheazine hydrochloride oral dissolved film preparation and preparation method thereof | 山东则正医药技术有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-118754860-A | Carliplazine medicinal salt and crystal form, preparation method and application thereof | 上海云晟研新生物科技有限公司 | 2024-10-11 | — | — | CN | claimed |
| CN-118680906-A | Quick-dissolving-out calicheazine hydrochloride oral dissolved film preparation and preparation method thereof | 山东则正医药技术有限公司 | 2024-09-24 | — | — | CN | claimed |
| CN-118526462-A | Carliplazine hydrochloride orally disintegrating tablet with similar dissolution behavior in different specifications and preparation method | 山东则正医药技术有限公司 | 2024-08-23 | — | — | CN | claimed |
| EP-3444336-B1 | CLEANING AGENT | PROCTER & GAMBLE (US) | 2024-05-08 | — | — | EP | claimed |
| CN-117243955-A | Carragazine hydrochloride pharmaceutical composition and capsule preparation containing same | 杭州和康药业有限公司 | 2023-12-19 | — | — | CN | claimed |
| US-20230003721-A1 | MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2023-01-05 | — | — | US | claimed |
| CN-114634479-A | Piperazine derivative, preparation method and application thereof | 北京盈科瑞创新药物研究有限公司 | 2022-06-17 | — | — | CN | claimed |
| US-11344046-B2 | Compositions to increase milk fat production in lactating ruminants and methods using the same | NUTRECO NEDERLAND B.V. (NL) | 2022-05-31 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| WO-1997040127-A1 | BLEACHING OF FABRIC WITH A HYBRID ENZYME CONTAINING A PHENOL OXIDIZING ENZYME FUSED TO A CELLULOSE BINDING DOMAIN | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | claimed |
| WO-1997040229-A1 | FABRIC TREATED WITH A CELLULASE AND A HYBRID ENZYME COMPRISING A PHENOL OXIDIZING ENZYME | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | claimed |
| WO-1997025469-A1 | TEXTILES BLEACHING/BRIGHTENING | NOVO NORDISK A/S (DK) | 1997-07-17 | — | — | WO | claimed |
| WO-1997025468-A1 | FABRIC TREATED WITH CELLULASE AND OXIDOREDUCTASE | NOVO NORDISK A/S (DK) | 1997-07-17 | — | — | WO | claimed |
| WO-1997011217-A1 | STAIN BLEACHING | NOVO NORDISK A/S (DK) | 1997-03-27 | — | — | WO | claimed |
| US-5288502-A | Drug delivery | THE UNIVERSITY OF TEXAS SYSTEM (US) | 1994-02-22 | — | — | US | claimed |
| WO-1993007861-A1 | PREPARATION AND USES OF MULTI-PHASE MICROSPHERES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| EP-0160806-B1 | PREPOLYMERS PREPARED FROM HYDROXY-AROMATIC MONO-ALDEHYDES AND METHYLATED PYRIDINES OR PYRAZINES, AND COMPOSITES PREPARED THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1989-02-08 | — | — | EP | claimed |