Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.90 |
| ▸ | HTR1A | P08908 | 5/20 | 0.90 |
| ▸ | TP53 | P04637 | 5/20 | 0.90 |
| ▸ | KDM1A | O60341 | 4/20 | 0.90 |
| ▸ | DRD2 | P14416 | 4/20 | 0.90 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.90 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.90 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.90 |
| ▸ | DRD1 | P21728 | 4/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.90 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.90 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.90 |
| ▸ | DRD3 | P35462 | 4/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.90 |
| ▸ | THPO | P40225 | 4/20 | 0.90 |
| ▸ | MTOR | P42345 | 4/20 | 0.90 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promazine SCHEMBL29392545 | 0.95 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL140489 | 0.95 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL9052694 | 0.95 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL123418 | 0.93 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL27425063 | 0.93 | CYP2D6 (0.97) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL29390978 | 0.93 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL27429489 | 0.93 | CYP2D6 (0.97) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL123419 | 0.92 | CYP2D6 (0.94) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL28239574 | 0.90 | CYP2D6 (0.91) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Fenethazine SCHEMBL29394568 | 0.88 | KDM1A (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030032801-A1 | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2003-02-13 | — | — | US | claimed |
| WO-2002089810-A1 | CHEMOSENSITIZING AGENTS AGAINST CHLOROQUINE RESISTANT PLASMODIUM FALCIPARUM AND METHODS OF MAKING AND USING THEREOF | UNITED STATES ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2002-11-14 | — | — | WO | claimed |
| US-6800618-B2 | PHENOTHIAZINE OR IMINODIBENZYL DERIVATIVES AS ANTIMALARIAL AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2004-10-05 | — | — | US | disclosed |
| US-20030032801-A1 | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2003-02-13 | — | — | US | disclosed |
| WO-2002089810-A1 | CHEMOSENSITIZING AGENTS AGAINST CHLOROQUINE RESISTANT PLASMODIUM FALCIPARUM AND METHODS OF MAKING AND USING THEREOF | UNITED STATES ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030032801-A1 | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof | ABCC1, SLC11A2, G6PD | CYP2D6 31/4885CYP1A2 374/4885HTR1A 3269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.