Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.97 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 5/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | GFER | P55789 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.97 |
| ▸ | HTR1A | P08908 | 6/20 | 0.97 |
| ▸ | TP53 | P04637 | 5/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.97 |
| ▸ | DRD1 | P21728 | 5/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promazine SCHEMBL123418 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL140489 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL29392545 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL9052694 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL27429489 | 0.97 | CYP2D6 (0.97) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL27425063 | 0.97 | CYP2D6 (0.97) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL123419 | 0.95 | CYP2D6 (0.94) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Promazine SCHEMBL28239574 | 0.94 | CYP2D6 (0.91) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| SCHEMBL6865346 | 0.93 | CYP2D6 (0.90) | LMNAMAPTSMN1; SMN2PMP22NPSR1 | |
| Fenethazine SCHEMBL662746 | 0.90 | KDM1A (0.96) | LMNAMAPTSMN1; SMN2PMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116574117-A | Method for synthesizing asymmetric substitution reaction intermediate | 华南理工大学 | 2023-08-11 | — | — | CN | claimed |
| US-20250107307-A1 | SUBSTITUTIONAL BORON DOPANTS IN TRIPHENLYENE MOTIF FOR PHOTOVOLTAIC OR PHOTODIODE APPLICATIONS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2025-03-27 | — | — | US | disclosed |
| US-20240145031-A1 | Methods and devices for drug repositioning and drug repurposing as nuclear receptor modulators | Precision Medicine Lab (NL) | 2024-05-02 | — | — | US | disclosed |
| CN-116574117-A | Method for synthesizing asymmetric substitution reaction intermediate | 华南理工大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-115073552-A | Polypeptide, hydrogel and application thereof | 湖南大学 | 2022-09-20 | — | — | CN | disclosed |
| US-11246873-B2 | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-02-15 | — | — | US | disclosed |