Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fenethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 5/20 | 0.78 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.78 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.78 |
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.78 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.78 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.78 |
| ▸ | DRD1 known ✓ | P21728 | 4/20 | 0.78 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.78 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.78 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.78 |
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.78 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.78 |
| ▸ | KCNH2 known ✓ | Q12809 | 4/20 | 0.78 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.78 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.78 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.78 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.78 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.78 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.78 |
| ▸ | HRH2 known ✓ | P25021 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenethazine SCHEMBL144367 | 0.98 | KDM1A (1.00) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Fenethazine SCHEMBL29394568 | 0.98 | KDM1A (1.00) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Promazine SCHEMBL123418 | 0.90 | LMNA (1.00) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Promazine SCHEMBL29390978 | 0.90 | LMNA (1.00) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Promazine SCHEMBL140489 | 0.88 | CYP2D6 (1.00) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Promazine SCHEMBL29392545 | 0.88 | CYP2D6 (1.00) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Promazine SCHEMBL9052694 | 0.88 | CYP2D6 (1.00) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Cholrphenethazine SCHEMBL9724481 | 0.87 | ITGB2 (0.97) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| Cholrphenethazine SCHEMBL29376339 | 0.87 | ITGB2 (0.97) | KDM1ALMNAMAPTSMN1; SMN2PMP22 | |
| SCHEMBL6865346 | 0.86 | CYP2D6 (0.90) | KDM1ALMNAMAPTSMN1; SMN2PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757376-B2 | Pharmaceutical compositions | GM PHARMACEUTICALS, INC. (US) | 2017-09-12 | — | — | US | claimed |
| EP-1641446-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF | Pediamed Pharmaceuticals, Inc. (US) | 2006-04-05 | — | — | EP | claimed |
| WO-2005094832-A1 | COMPOSITIONS COMPRISING MELOXICAM | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-13 | — | — | WO | claimed |
| WO-2004112771-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF | PEDIAMED PHARMACEUTICALS, INC. (US) | 2004-12-29 | — | — | WO | claimed |
| US-20040259809-A1 | Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof | PEDIAMED PHARMACEUTICALS, INC. | 2004-12-23 | — | — | US | claimed |
| EP-4692178-A1 | CELLULOSE POWDER AND MOLDED BODY | Asahi Kasei Kabushiki Kaisha (JP) | 2026-02-11 | — | — | EP | disclosed |
| WO-2025121315-A1 | CELLULOSE POWDER AND MOLDED BODY | 旭化成株式会社 | 2025-06-12 | — | — | WO | disclosed |
| WO-2025105451-A1 | SOLID PREPARATION | 第一三共ヘルスケア株式会社 | 2025-05-22 | — | — | WO | disclosed |
| WO-2025100523-A1 | METHOD FOR PRODUCING SOLID PREPARATION, AND TABLETS | 第一三共ヘルスケア株式会社 | 2025-05-15 | — | — | WO | disclosed |
| WO-2025100462-A1 | SOLID COMPOSITION CONTAINING BROMHEXINE | 第一三共ヘルスケア株式会社 | 2025-05-15 | — | — | WO | disclosed |
| EP-4056637-B1 | CELLULOSE COMPOSITION AND TABLET | ASAHI CHEMICAL IND (JP) | 2025-02-12 | — | — | EP | disclosed |
| CN-119278035-A | Solid preparation and method for producing the same | 第一三共健康事业株式会社 | 2025-01-07 | — | — | CN | disclosed |
| WO-2004041263-A1 | NEW PHARMACEUTICAL COMPOSITIONS CONTAINING AMBROXOL AND ISOPROPAMIDE IODIDE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-05-21 | — | — | WO | disclosed |
| EP-1417961-A1 | New pharmaceutical compositions containing a combination of ambroxol or bromhexine and isopropamide iodide | Boehringer Ingelheim International GmbH (DE) | 2004-05-12 | — | — | EP | disclosed |
| EP-1391201-A1 | MEDICINAL COMPOSITIONS | SSP Co., Ltd. (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1391200-A1 | DRUG PREPARATIONS | SSP Co., Ltd. (JP) | 2004-02-25 | — | — | EP | disclosed |
| US-6071962-A | IN TOPICAL APPLICATIONS TO TREAT VARIOUS SKIN CONDITIONS ATTRIBUTED TO, ACCOMPANIED BY OR EXACERBATED BY ABNORMAL DESQUAMATION INCLUDING DRY SKIN, ICHTHYOSIS, PALMAR AND PLANTAR HYPERKERATOSES, DANDRUFF, LICHEN SIMPLEX CHRONICUS | AVON PRODUCTS, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| US-5847003-A | Oxa acids and related compounds for treating skin conditions | AVON PRODUCTS, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5834513-A | TOPICAL COMPOSITION FOR TREATING SKIN CONDITIONS CHARACTERIZED BY ABNORMAL DESQUAMATION | AVON PRODUCTS, INC. (US) | 1998-11-10 | — | — | US | disclosed |
| US-5409709-A | Coating a layer of ibuprofen, a layer of magnesium-based antacid and a layer between the above layers of acetaminophen; sustained release; antiinflammatory agent | LION CORPORATION (JP) | 1995-04-25 | — | — | US | disclosed |