Promazine

Promazine

SCHEMBL123419

CN(C)CCCN1c2ccccc2Sc2ccccc21.[Cl-].[H+]

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

DRD2DRD3DRD4HTR2A

The experimentally established mechanism targets of Promazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 known ✓ P14416 5/20 0.94
DRD3 known ✓ P35462 5/20 0.94
DRD4 known ✓ P21917 3/20 0.94
HTR2A known ✓ P28223 3/20 0.94
CYP2D6 P10635 10/20 0.94
CYP1A2 P05177 8/20 0.94
HTR1A P08908 6/20 0.94
TP53 P04637 5/20 0.94
CHRM2 P08172 5/20 0.94
CHRM1 P11229 5/20 0.94
DRD1 P21728 5/20 0.94
SLC6A2 P23975 5/20 0.94
SLC6A4 P31645 5/20 0.94
ADRA1A P35348 5/20 0.94
OPRM1 P35372 5/20 0.94
KCNH2 Q12809 5/20 0.94
MTOR P42345 5/20 0.94
KDM1A O60341 4/20 0.94
CYP2C19 P33261 4/20 0.94
ADRA2A P08913 4/20 0.94

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Promazine SCHEMBL28239574 0.98 CYP2D6 (0.91) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL9052694 0.97 CYP2D6 (1.00) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL29392545 0.97 CYP2D6 (1.00) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL140489 0.97 CYP2D6 (1.00) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL29390978 0.95 LMNA (1.00) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL27425063 0.95 CYP2D6 (0.97) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL27429489 0.95 CYP2D6 (0.97) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL123418 0.95 LMNA (1.00) CYP2D6CYP1A2HTR1ATP53DRD2
SCHEMBL6865346 0.92 CYP2D6 (0.90) CYP2D6CYP1A2HTR1ATP53DRD2
Promazine SCHEMBL6855138 0.88 CYP2D6 (0.83) CYP2D6CYP1A2HTR1ATP53DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 916 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3444337-B1 METHOD OF CLEANING PROCTER & GAMBLE (US) 2024-12-18 EP claimed
CN-118526462-A Carliplazine hydrochloride orally disintegrating tablet with similar dissolution behavior in different specifications and preparation method 山东则正医药技术有限公司 2024-08-23 CN claimed
EP-3444336-B1 CLEANING AGENT PROCTER & GAMBLE (US) 2024-05-08 EP claimed
US-20230003721-A1 MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2023-01-05 US claimed
US-11344046-B2 Compositions to increase milk fat production in lactating ruminants and methods using the same NUTRECO NEDERLAND B.V. (NL) 2022-05-31 US claimed
US-20210147765-A9 CLEANING KIT THE PROCTER AND GAMBLE COMPANY 2021-05-20 US claimed
CN-110892065-A Cleaning method 宝洁公司 2020-03-17 CN claimed
US-20200063073-A1 METHOD OF CLEANING THE PROCTER AND GAMBLE COMPANY 2020-02-27 US claimed
US-20200063072-A1 CLEANING KIT PROCTER & GAMBLE (US) 2020-02-27 US claimed
EP-2956119-B1 NANOPARTICLE DELIVERY COMPOSITIONS MIDATECH LTD (GB) 2019-08-14 EP claimed
US-5851233-A Bleaching process comprising use of a phenol oxidizing enzyme, a hydrogen peroxide source and an enhancing agent NOVO NORDISK A/S (DK) 1998-12-22 US claimed
WO-1998018610-A1 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES LENGERICH BERNHARD H VAN (US) 1998-05-07 WO claimed
WO-1997040127-A1 BLEACHING OF FABRIC WITH A HYBRID ENZYME CONTAINING A PHENOL OXIDIZING ENZYME FUSED TO A CELLULOSE BINDING DOMAIN NOVO NORDISK A/S (DK) 1997-10-30 WO claimed
WO-1997040229-A1 FABRIC TREATED WITH A CELLULASE AND A HYBRID ENZYME COMPRISING A PHENOL OXIDIZING ENZYME NOVO NORDISK A/S (DK) 1997-10-30 WO claimed
WO-1997025469-A1 TEXTILES BLEACHING/BRIGHTENING NOVO NORDISK A/S (DK) 1997-07-17 WO claimed
WO-1997025468-A1 FABRIC TREATED WITH CELLULASE AND OXIDOREDUCTASE NOVO NORDISK A/S (DK) 1997-07-17 WO claimed
WO-1997011217-A1 STAIN BLEACHING NOVO NORDISK A/S (DK) 1997-03-27 WO claimed
US-5288502-A Drug delivery THE UNIVERSITY OF TEXAS SYSTEM (US) 1994-02-22 US claimed
WO-1993007861-A1 PREPARATION AND USES OF MULTI-PHASE MICROSPHERES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1993-04-29 WO claimed
EP-0351897-A2 Skin penetration system for salts of amine-functional drugs THE PROCTER & GAMBLE COMPANY (US) 1990-01-24 EP claimed