Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.97 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 3/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.97 |
| ▸ | HTR1A | P08908 | 6/20 | 0.97 |
| ▸ | TP53 | P04637 | 5/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.97 |
| ▸ | DRD1 | P21728 | 5/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.97 |
| ▸ | MTOR | P42345 | 5/20 | 0.97 |
| ▸ | KDM1A | O60341 | 4/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promazine SCHEMBL9052694 | 0.98 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL29392545 | 0.98 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL140489 | 0.98 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL28239574 | 0.97 | CYP2D6 (0.91) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL29390978 | 0.97 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL123418 | 0.97 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL27425063 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL123419 | 0.95 | CYP2D6 (0.94) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| SCHEMBL6865346 | 0.93 | CYP2D6 (0.90) | CYP2D6CYP1A2HTR1ATP53DRD2 | |
| Promazine SCHEMBL6855138 | 0.90 | CYP2D6 (0.83) | CYP2D6CYP1A2HTR1ATP53DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103083335-A | Compound sulfachlorpromazine sodium tablet for pets and preparation method thereof | QINGDAO CONTINENT PHARM CO LTD | 2013-05-08 | — | — | CN | claimed |
| CN-104840453-A | Traditional Chinese medicine composition for curing chicken coccidiosis as well as preparation method and application thereof | LANZHOU INST ANIMAL SCIENCE & VETERINARY PHARMACEUTICS CAAS | 2015-08-19 | — | — | CN | disclosed |
| CN-103083335-A | Compound sulfachlorpromazine sodium tablet for pets and preparation method thereof | QINGDAO CONTINENT PHARM CO LTD | 2013-05-08 | — | — | CN | disclosed |
| CN-102028676-A | Application of triclosan to resistance to Eimeria tenella | VETERINARY RES INST GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES | 2011-04-27 | — | — | CN | disclosed |
| CN-1160129-C | Process for preparing medicines with no or low loxic by-effect on gastrointestinal system | 王 晓 | 2004-08-04 | — | — | CN | disclosed |
| CN-1129429-C | potassium, sodium and tris oxaprozin salt pharmaceutical formulations | G D SEARLER & CO (US) | 2003-12-03 | — | — | CN | disclosed |
| CN-1276246-A | Process for preparing medicines with no or low loxic by-effect on gastrointestinal system | WANG XIAO (CN) | 2000-12-13 | — | — | CN | disclosed |