Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.83 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.83 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.83 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.83 |
| ▸ | HTR1A | P08908 | 5/20 | 0.83 |
| ▸ | TP53 | P04637 | 5/20 | 0.83 |
| ▸ | KDM1A | O60341 | 4/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.83 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.83 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.83 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.83 |
| ▸ | DRD1 | P21728 | 4/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.83 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.83 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.83 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promazine SCHEMBL140489 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL9052694 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL29392545 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL27425063 | 0.90 | CYP2D6 (0.97) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL27429489 | 0.90 | CYP2D6 (0.97) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL29390978 | 0.90 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL123418 | 0.90 | LMNA (1.00) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Chlorpromazine SCHEMBL3198978 | 0.89 | CYP1A2 (0.86) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL123419 | 0.88 | CYP2D6 (0.94) | CYP2D6CYP1A2HTR1ATP53KDM1A | |
| Promazine SCHEMBL28239574 | 0.87 | CYP2D6 (0.91) | CYP2D6CYP1A2HTR1ATP53KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003062388-A9 | INHIBITION OF RNA FUNCTION | UNIV CALIFORNIA (US) | 2004-05-27 | — | — | WO | disclosed |
| US-20030229082-A1 | Inhibition of RNA function | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-12-11 | — | — | US | disclosed |
| WO-2003062388-A2 | INHIBITION OF RNA FUNCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229082-A1 | Inhibition of RNA function | OPRM1, EFTUD2, POLRMT | DRD2 675/4885DRD3 1336/4885DRD4 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.