SCHEMBL123530

SCHEMBL123530

CNC(=O)C(=NOC)c1ccccc1CON=C(C)c1cccc(C(F)(F)F)c1

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 0.52
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
GAA P10253 1/20 0.41
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40
RXFP1 Q9HBX9 4/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TP53 P04637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL123529 1.00 HIF1A (0.52) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL30354029 1.00 HIF1A (0.52) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL29765420 1.00 HIF1A (0.52) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL14141835 1.00 HIF1A (0.52) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL828172 1.00 HIF1A (0.52) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL483559 1.00 HIF1A (0.52) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL30158137 0.92 MEN1 (0.45) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL13278820 0.92 MEN1 (0.45) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL168688 0.92 MEN1 (0.45) HIF1AMEN1KMT2AGAAPPARG
SCHEMBL168689 0.92 MEN1 (0.45) HIF1AMEN1KMT2AGAAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 843 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3010893-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2019-10-02 EP claimed
EP-3010889-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-10-03 EP claimed
EP-2793578-B1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-06-06 EP claimed
US-20180103640-A1 PROCESS FOR IMPROVING SEEDLING GROWTH AND/OR EARLY EMERGENCE OF CROPS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-04-19 US claimed
US-20170265470-A1 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-21 US claimed
US-9642363-B2 N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides BAYER CROPSCIENCE AG (DE) 2017-05-09 US claimed
US-20160150785-A1 Synergistic Fungicidal Active Substance Combinations BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-06-02 US claimed
US-20160130240-A1 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-05-12 US claimed
US-20160128331-A1 ANTHRANILAMIDES IN COMBINATION WITH FUNGICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-05-12 US claimed
EP-2997825-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND A FUNGICIDAL COMPOUND Bayer Intellectual Property GmbH (DE) 2016-03-23 EP claimed
US-20110009267-A1 Process for Improving Seedling Growth and/or Early Emergence of Crops BAYER CROPSCIENCE AG (DE) 2011-01-13 US claimed
EP-2272345-A1 Process for improving seedling growth and/or early emergence of crops Bayer CropScience AG (DE) 2011-01-12 EP claimed
US-20110003689-A1 USE OF POLYMERIC GUANIDINE DERIVATIVES FOR THE CONTROL OF UNWANTED MICROORGANISMS IN CROP PROTECTION AKA TECHNOLOGY GMBH (AT) 2011-01-06 US claimed
EP-2269454-A1 Combinations of fungicidally active yeast and fungicides Bayer CropScience AG (DE) 2011-01-05 EP claimed
US-20100273648-A1 Synergistic Fungicidal Active Substance Combinations BAYER CROPSCIENCE AG (DE) 2010-10-28 US claimed
EP-1893024-B1 ACTIVE SUBSTANCE COMBINATIONS BAYER CROPSCIENCE AG (DE) 2010-10-13 EP claimed
US-20100190645-A1 SYNERGISTIC FUNGICIDAL ACTIVE COMPOUND COMBINATIONS COMPRISING FORMONONETIN PLANT HEALTH CARE, INC. 2010-07-29 US claimed
US-20090280981-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2009-11-12 US claimed
US-20090018015-A1 Synergistic Fungicidal Active Combinations BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2009-01-15 US claimed
US-20070060579-A1 Synergistic fungicidal active substance combinations BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-03-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100273648-A1 Synergistic Fungicidal Active Substance Combinations GLRA1, GRM1, CYP1A2 HIF1A 3982/4885MEN1 2134/4885KMT2A 1733/4885
US-20110003689-A1 USE OF POLYMERIC GUANIDINE DERIVATIVES FOR THE CONTROL OF UNWANTED MICROORGANISMS IN CROP PROTECTION GDA, GMPS, GANC HIF1A 3165/4885MEN1 4049/4885KMT2A 1945/4885
US-20090018015-A1 Synergistic Fungicidal Active Combinations CYP51A1, CYP1A2, CYP3A7 HIF1A 4714/4885MEN1 1718/4885KMT2A 1555/4885
US-20180103640-A1 PROCESS FOR IMPROVING SEEDLING GROWTH AND/OR EARLY EMERGENCE OF CROPS EEF1A1, BTF3, EEF1A2 HIF1A 1481/4885MEN1 4759/4885KMT2A 1570/4885
US-20160150785-A1 Synergistic Fungicidal Active Substance Combinations CYP1A2, CAT, CYP51A1 HIF1A 4570/4885MEN1 1515/4885KMT2A 2163/4885
US-20160130240-A1 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES ARSA, SQOR, AHR HIF1A 4557/4885MEN1 4833/4885KMT2A 2528/4885
US-20070060579-A1 Synergistic fungicidal active substance combinations CYP51A1, CYP1A2, CYP4X1 HIF1A 4170/4885MEN1 1780/4885KMT2A 2104/4885
US-20110009267-A1 Process for Improving Seedling Growth and/or Early Emergence of Crops EEF1A1, BTF3, EEF1A2 HIF1A 1481/4885MEN1 4759/4885KMT2A 1570/4885
US-20100190645-A1 SYNERGISTIC FUNGICIDAL ACTIVE COMPOUND COMBINATIONS COMPRISING FORMONONETIN CYP51A1, ERG28, CYP3A7 HIF1A 4816/4885MEN1 196/4885KMT2A 3587/4885
US-20160128331-A1 ANTHRANILAMIDES IN COMBINATION WITH FUNGICIDES AADAC, ANTXR2, CYP51A1 HIF1A 3943/4885MEN1 1806/4885KMT2A 388/4885
US-20090280981-A1 SYNERGISTIC ACTIVE INGREDIENT COMBINATIONS CYP51A1, ERG28, CYP4X1 HIF1A 4728/4885MEN1 2860/4885KMT2A 2897/4885
US-20170265470-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 HIF1A 3943/4885MEN1 1806/4885KMT2A 388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.