Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366188 | 0.83 | LMNA (0.47) | LMNAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL12366100 | 0.83 | ALDH1A1 (0.56) | LMNAHPGDRAB9AALDH1A1TP53 | |
| SCHEMBL12366096 | 0.83 | L3MBTL1 (0.57) | HPGDALDH1A1KMT2APOLBCA12 | |
| SCHEMBL12366142 | 0.83 | KMT2A (0.59) | HTTHPGDRAB9AALDH1A1KMT2A | |
| SCHEMBL11591975 | 0.82 | GAA (0.59) | LMNAHTTHPGDRAB9AALDH1A1 | |
| SCHEMBL12366117 | 0.82 | HDAC1 (0.56) | LMNARAB9AALDH1A1TP53POLB | |
| SCHEMBL12366168 | 0.82 | P2RX7 (0.44) | LMNAALDH1A1KMT2AMAOB | |
| SCHEMBL12366208 | 0.81 | SRC (0.57) | RAB9AALDH1A1TP53KMT2APOLB | |
| SCHEMBL12366121 | 0.80 | LMNA (0.64) | LMNAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6366481 | 0.79 | ALDH1A1 (0.57) | LMNAHTTRAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |