Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CLPP | Q16740 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366212 | 0.91 | CNR1 (0.44) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12366418 | 0.90 | MAPT (0.42) | RXRANR1H2NR1H3GRIN1GRIN2B | |
| SCHEMBL12366278 | 0.89 | MAPT (0.45) | POLBALDH1A1KDM4EMAPTPPARG | |
| SCHEMBL12366308 | 0.89 | RXRA (0.43) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12366241 | 0.88 | CNR1 (0.42) | POLBALDH1A1KDM4EHTTMAPT | |
| SCHEMBL12366441 | 0.88 | LMNA (0.43) | RXRANR1H2NR1H3POLBALDH1A1 | |
| SCHEMBL12366421 | 0.87 | RXRA (0.39) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12366238 | 0.86 | DCTPP1 (0.42) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12366226 | 0.85 | RGS4 (0.43) | GRIN1GRIN2BMAPTCNR1LMNA | |
| SCHEMBL12366275 | 0.84 | CFTR (0.42) | RXRANR1H2NR1H3KDM4EPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |